Delta Secretase and BDNF Signalling in Alzheimer’s Disease
Authors : Buse ÜNLÜ, Sümeyra ILDIZ, Duygun GEZEN AK, Erdinç DURSUN
Pages : 1-7
Doi:10.26650/experimed.1231893
View : 25 | Download : 9
Publication Date : 2023-05-11
Article Type : Review Paper
Abstract :As one of the major contributors of the central nervous system, neurons require neurotrophic factors, which are synthesized from neighbouring cells, for several cellular processes, such as neuronal survival, growth, and differentiation. Neurotrophic factors are categorized into the neurotrophin family, the neuropoietic cytokines, and the glial cell-derived neurotrophic factor. The neurotrophin family comprises four growth factors: nerve growth factor insert ignore into journalissuearticles values(NGF);, neurotrophin-3 insert ignore into journalissuearticles values(NT3);, neurotrophin-4 insert ignore into journalissuearticles values(NT4);, and brain-derived neurotrophic factor insert ignore into journalissuearticles values(BDNF);. One of the best-known neurotrophic factors is BDNF. Its importance is based on its central role in neuronal survival. Entry of the BDNF into the neurons occurs via TrkB receptors, and it is transported to the cell body along microtubules in axons. As it is known in the brains of Alzheimer\`s patients, the axonal transport of BDNF is destructed via the hyperphosphorylated tau. There are several causes for the hyperphosphorylation of tau. Among them, delta secretase insert ignore into journalissuearticles values(δ-secretase);, a lysosomal cysteine protease, cleaves both amyloid precursor protein insert ignore into journalissuearticles values(APP); and tau. It is supposed to play an essential role in tau hyperphosphorylation, particularly in the aging brain. In this review, we focus on the activity of δ-secretase, how it leads to tau hyperphosphorylation, and how it disrupts the axonal transport of BDNF in Alzheimer\`s diseaseKeywords : BDNF, axonal transport, delta secretase, Alzheimers disease, APP, tau protein
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