The association between low serum vitamin-B12 levels and hyperpigmentation in patients who use isotretinonin

Authors : Sevim BAYSAK, Ebru KARAGÜN, Havva Hilal AYVAZ
Pages : 19-24
Doi:10.26900/hsq.1.1.04
View : 28 | Download : 4
Publication Date : 2021-04-30
Article Type : Research Paper
Abstract :Oral isotretinoin is the most effective agent in the treatment of acne vulgaris. The risk of pigmentation due to the systemic isotretinoin may be associated with decrease in serum levels of vitamin B12. The study aims to contribute to the literature by defining the association between the increase in pigmentation caused by oral isotretinoin insert ignore into journalissuearticles values(O-ISO); use and low vitamin B12 level insert ignore into journalissuearticles values(vit-B12);. In our study we evaluated 144 patients who have facial acnes at medium degree according to FDA Acne Score and take O-ISO treatment with the dose 0.5 mg/ kg/ day for six months. The mean vit-B12 levels of the patients at the admission and 6th month and the existence of pigmentation at 6th month, the skin type and the skin layer at which the pigmentation occurs were evaluated. Association of vit-B12 level on admission and six months post drug use with the presence of pigmentation at six months, the type of skin and the skin layer in which pigmentation occurs were evaluated. In the patient group with pigmentation, the mean vit-B12 level after six months of drug use was statistically lower than the mean vit-B12 level on admission insert ignore into journalissuearticles values(p<0.001);. In patients without pigmentation, difference between the mean levels of vit-B12 levels was not statistically significant insert ignore into journalissuearticles values(p = 0,255);. As a result, it was determined that the mean vit-B12 level decreased due to O-ISO use and the association of hyperpigmentation and low vit-B12 level was statistically significant. Vit-B12 monitoring and supplementation, if necessary, can help us to prevent hyperpigmentation that may occur during the treatment
Keywords : sotretinonin, hyperpigmentation, vitamin B12, side effect

ORIGINAL ARTICLE URL