Skeletal Dentoalveolar and Soft Tissue Effects of β Thalassemia Major

Authors : Atılım AKKURTA, Mehmet DOGRU, Arzum Guler DOGRU, Kamile KESKİN

Pages : 39-49

View : 17 | Download : 5

Publication Date : 2017-12-01

Article Type : Research Paper

Abstract :Objective: Thalassemia insert ignore into journalissuearticles values(TH); is a genetic disorder of hemoglobin synthesis caused by the absence or reduced synthesis of globin chains which causes different craniofacial effects. The purpose of this study is to evaluate the skeletal, dental and soft tissue cephalometric features of TH patients. Materials and Methods: Present study consisted of lateral cephalometric images obtained from CBCT scans of 25 TH insert ignore into journalissuearticles values(mean age: 13,7±3,8 years); and 50 normal insert ignore into journalissuearticles values(mean age: 13,9±1,81 years); individuals. An Independent sample t was used to compare the cephalometric measurements. Results: TH patients revealed a high angle Class II pattern insert ignore into journalissuearticles values(SnGoMe, Sum p<0,01, ANS-PNS/GoMe, ANB, p<0,001); caused by retruded mandible insert ignore into journalissuearticles values(SNB, SNPog, p<0,001); with retrusive upper insert ignore into journalissuearticles values(U1-Na°, p<0,01, U1-Na mm p<0,001); and protrusive lower incisors insert ignore into journalissuearticles values(L1Nb °, p<0,001, IMPA, p<0,05, L1Nb mm, p<0,01);. Except the S-N length insert ignore into journalissuearticles values(p>0.05);, all craniofacial parameters insert ignore into journalissuearticles values(S-Ar p<0,05, S-Go p<0,01, Ar-Go, N-Me p<0,05, Go-Me, S-Go/N-Me p<0,001); of TH patients’ found significantly smaller than that obtained from normal individuals. On the contrary ANS-PNS parameter insert ignore into journalissuearticles values(p<0,01); was found significantly bigger in TH patients’. In addition TH patients have protrusive upper insert ignore into journalissuearticles values(p<0,05); and lower lips insert ignore into journalissuearticles values(p<0,01); accompanied with an increased nasolabial angle insert ignore into journalissuearticles values(p<0,01); when compared with normal individuals. Conclusion: A high angle Class II pattern caused by the retrusion and clockwise rotation of mandible accompanied with retrusive upper, protrusive lower incisors and protrusive upper and lower lips may be considered the most common craniofacial features of TH patients.
Keywords : protrusive