Effect of Subthalamic Nucleus Deep Brain Stimulation Treatment on Non-motor Symptoms and Sleep Quality in Parkinson’s Disease Patients

Authors : Nazan ŞİMŞEK ERDEM, Gokce Yagmur GUNES GENCER, Sehür Sibel ÖZKAYNAK, Tanju UÇAR

Pages : 59-65

Doi:10.30565/medalanya.1221314

View : 36 | Download : 40

Publication Date : 2023-06-21

Article Type : Research Paper

Abstract :Aim: To evaluate the effect of subthalamic nucleus deep brain stimulation insert ignore into journalissuearticles values(STN-DBS); on non-motor symptoms insert ignore into journalissuearticles values(NMS);, sleep quality, and excessive daytime sleepiness in patients with Parkinson’s Disease insert ignore into journalissuearticles values(PD);. Method: Sixteen PD patients, who had undergone bilateral STN-DBS surgery were enrolled. The patients were assessed at the baseline and 12 months after surgery using the Unified Parkinson\`s Disease Rating Scale insert ignore into journalissuearticles values(UPDRS);, Parkinson\`s Disease Questionnaire insert ignore into journalissuearticles values(PDQ-39);, Beck Depression Inventory-II insert ignore into journalissuearticles values(BDI);, Hospital Anxiety and Depression Scale insert ignore into journalissuearticles values(HADS);, Pittsburgh Sleep Quality Index insert ignore into journalissuearticles values(PSQI);, Epworth Sleepiness Scale insert ignore into journalissuearticles values(ESS);, and Non-Motor Symptom Questionnaire insert ignore into journalissuearticles values(NMS-Quest);. Results: The mean age of the patients at the time of surgery was 53.5±3.6 years. There were significant improvements in the levodopa-equivalent daily dose, UPDRS-part-II, UPDRS-part-III, and UPDRS-part-IV at 12 months post-DBS surgery. The NMS-Quest total score at baseline was correlated with the disease duration of the patients insert ignore into journalissuearticles values(p=0.005 R:0.66);. The PSQI score at baseline was significantly associated with a high total UPDRS and HADS score insert ignore into journalissuearticles values(p=0.03, p=0.004 respectively);. There were no significant differences in terms of NMS-Quest total and subdomains thereof and PSQI total score and subdomains thereof, UPDRS-part I, BDI-II and HADS scores between baseline and 12 months post-DBS surgery insert ignore into journalissuearticles values(p>0.05 for all of them);. Conclusion: STN-DBS surgery did not change subjective sleep quality, excessive daytime sleepiness, and NMS although it improved motor symptoms, motor fluctuations, and the health-related quality of life
Keywords : subtalamik nukleus derin beyin stimülasyonu STN DBS, uyku kalitesi, non semptomlar, gündüz aşırı uykululuk hali