Vitamin D, VDR, and VDBP Levels Correlate with Anti-inflammatory Cytokine Profile in FMS Patients

Authors : Pınar ELLERGEZEN, Alev ALP, Sinan ÇAVUN

Pages : 24-8

Doi:10.37990/medr.1131305

View : 20 | Download : 7

Publication Date : 2023-01-15

Article Type : Research Paper

Abstract :Aim: The major target of this research is to examine whether there is any connection between the levels of vitamin D and anti-inflammatory mediators in patients with fibromyalgia syndrome insert ignore into journalissuearticles values(FMS);. Materials and Methods: The study contains 30 FMS diagnosed and 25 healthy female individuals and the determination of FMS was made according to the standards of 2010 American College of Rheumatology insert ignore into journalissuearticles values(ACR);. Vitamin D, vitamin D receptor insert ignore into journalissuearticles values(VDR);, vitamin D binding protein insert ignore into journalissuearticles values(VDBP); levels, and anti-inflammatory cytokine insert ignore into journalissuearticles values(IL-4, IL-10, TGF-β); levels in the serum of patients with FMS and healthy individuals were measured using enzyme-linked immunosorbent assay insert ignore into journalissuearticles values(ELISA);. Results: The concentrations of vitamin D, VDR, and VDBP were determined to be higher in healthy controls than in patients with FMS insert ignore into journalissuearticles values(p<0.001);. Correlating with this, IL-4, IL-10, and TGF-β levels were measured remarkably higher in the healthy group than in the FMS patients insert ignore into journalissuearticles values(p<0.001);. Conclusion: Low vitamin D levels may cause a decrease in anti-inflammatory cytokine levels and their immunosuppressive effect in FMS.
Keywords : anti inflammatory cytokines, vitamin D, fibromyalgia syndrome