Evaluation of Atherosclerosis and Arterial Stiffness with Angiogenic Growth Factors in Chronic Kidney Disease Patients

Authors : Musa İlker Durak, Melahat Coban

Pages : 314-321

Doi:10.37990/medr.1603856

View : 65 | Download : 90

Publication Date : 2025-05-09

Article Type : Research Paper

Abstract :Aim: Cardiovascular (CV) complications are the most common cause of mortality in patients with chronic kidney disease (CKD).The study aimed to determine the relationship between angiopoietin-2 (Ang-2) and vascular endothelial growth factor (VEGF) and atherosclerosis as determined by carotid artery intima-media thickness (CAT) and arterial stiffness (AS) as determined by brachial-ankle pulse wave velocity (bPWV) in pre-dialysis CKD patients. Material and Method: The study included 126 (47.2%) male and 141 (52.8%) female pre-dialysis CKD patients. Presence of atherosclerosis was determined by CAT and presence of AS by bPWV. VEGF and Ang-2 serum levels were determined by enzyme-linked immunosorbent assays (ELISA). Results: CAT, bPWV, and log10 Ang-2 values were significantly higher in patients compared to the healthy control group. Estimated glomerular filtration rate (eGFR), C-reactive protein (CRP), total cholesterol, triglycerides, CAT, and bPWV were higher and spot urine protein creatinine ratio was lower in patients with high mean log10 Ang-2 compared to the patients with low mean log10 Ang-2. There was a significant correlation between log10 Ang-2 and bPWV and CAT, and an inverse relationship with log10 VEGF. Conclusion: Patients with CKD had increased development of atherosclerosis and AS, increased serum Ang-2 levels compared to healthy individuals. Ang-2 was significantly correlated with renal function and inversely correlated with proteinuria. Ang-2 was found to be correlated with inflammation and hyperlipidemia. A significant correlation was observed between Ang-2 and atherosclerosis and AS, and an inverse relationship was found with VEGF.
Keywords : Atherosclerosis, arterial stiffness, chronic kidney disease, angiopoietin-2, vascular endothelial growth factor

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