EVALUATION OF THE EFFECT OF INTRAVITREAL BEVACIZUMAB INJECTION ON SCLERAL THICKNESS WITH ANTERIOR SEGMENT OPTICAL COHERENCE TOMOGRAPHY

Authors : Mustafa ELİAÇIK, Sevil KARAMAN ERDUR

Pages : 31-35

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Publication Date : 2018-11-25

Article Type : Research Paper

Abstract :Abstract Purpose: To evaluate the changes of scleral thickness after repeated intravitreal injections of bevacizumab in a consecutive series of patients with anterior segment optical coherence tomography insert ignore into journalissuearticles values(AS-OCT);. Materials and Methods: The study group consisted of 54 eyes of 54 consecutive phakic patients who were indicated for the first time for intravitreal bevacizumab injection with a follow-up time of at least 12 months. The fellow eye of each patient formed the control group. Scleral thickness at the injection side was measured before the first intravitreal injection and after re-injections using AS-OCT. Results: Before treatment, scleral thickness was 610.5±22.9μm at the injection site and 608.17±22.2 μm at the same quadrant in fellow eye. After treatment scleral thickness was 604.8±22.3 μm at the injection site and 607.2±19.2 μm at the same quadrant in fellow eye. There was no statistically significant change both at injection site and other quadrants in the study and fellow eye at the end of follow-up period. The mean injection number was 9.44 ± 0.76. There was no significant correlation between the changes in scleral thickness and injection numbers insert ignore into journalissuearticles values(r=0.43, p=0.365);. Conclusions: Well-controlled intraocular pressure after intravitreal injections and more importantly molecular weight of injected material could probably prevent scleral thinning.
Keywords : intravitreal injections, sclera, optical coherence tomography, retina