Thymoquinone Ameliorates Indomethacin-Induced Gastric Ulcers in Rats: A Dose Response Study

Authors : Yasin BAYIR, Cemile TURAN, Yalçın KARAGÖZ, Abdulmecit ALBAYRAK, Beyzagül ERKAYMAN, Lale DUYSAK

Pages : 15-23

View : 22 | Download : 16

Publication Date : 2021-01-25

Article Type : Research Paper

Abstract :Nigella sativa L. essential oil is a widely used medicinal plant throughout the world. It is very popular in various traditional systems of medicine like Unani and Tibb, Ayurveda and Siddha. Acute and chronic use of non-steroidal anti-inflammatory drugs insert ignore into journalissuearticles values(NSAIDs); is considered a significant cause of peptic ulcers. Different doses insert ignore into journalissuearticles values(20-60 mg/kg body weight); of thymoquinone insert ignore into journalissuearticles values(TQ);, the main constituent of Nigella sativa L. essential oil, have been shown to protect gastric tissue from NSAID-induced peptic ulcers. Researchers attributed the protective effect of TQ to its antioxidant properties. This study aimed to determine effective antiulcer dose range of TQ. In this study, we conducted a series of experiments to determine the optimal dosage of TQ in indomethacin-induced gastric ulcers in rats. Additionally, we investigated the effect of TQ on superoxide dismutase insert ignore into journalissuearticles values(SOD); activity, glutathione insert ignore into journalissuearticles values(GSH); levels, and malondialdehyde insert ignore into journalissuearticles values(MDA); levels. Our results showed that, when administered at 40 and 20 mg/kg body weight, TQ was ineffective in preventing indomethacin-induced gastric ulcers. Moreover, TQ itself induced gastric ulcers at 40 mg/kg dose. As the doses of TQ decreased, the protective effect increased. 0.5 mg/kg TQ provided the best protection in terms of gastric ulcer area and antioxidant parameters, having statistically the same result with famotidine. Low dose TQ is an efficient protector of indomethacin-induced gastric damage, and it significantly enhances antioxidant parameters of gastric tissue. High dose TQ administration does not produce any desirable effects.
Keywords : Thymoquinone, Rats, Indomethacin induced gastric ulcer, SOD, GSH, MDA