The Neutrophil/Lymphocyte and Platelet/Lymphocyte Ratios of Pregnant Women Who Underwent the 75-g Oral Glucose Tolerance Test to Predict Gestational Diabetes

Authors : Yunus Emre TOPDAĞI, Çağdaş DEMİROĞLU, Ahmet Ziya ŞAHİN

Pages : 83-88

Doi:10.56766/ntms.1199230

View : 60 | Download : 65

Publication Date : 2023-05-26

Article Type : Research Paper

Abstract :Background: Gestational diabetes mellitus insert ignore into journalissuearticles values(GDM); is one of the most common medical complications of pregnancy. Early diagnosis and treatment are important; the condition can cause both maternal and foetal complications. Today, single-/double-bolus oral 50–100-g glucose tolerance tests insert ignore into journalissuearticles values(OGTTs); are preferred. We explored whether the peripheral blood platelet/lymphocyte ratio insert ignore into journalissuearticles values(PLR); and/or neutrophil/lymphocyte ratio insert ignore into journalissuearticles values(NLR); could guide diabetes screening of a target group insert ignore into journalissuearticles values(rather than all pregnant women);. Materials and Methods: This retrospective study was conducted at the Obstetrics and Gynecology Clinic of Sanko University Hospital from January 2010 to January 2020. Pregnant women in gestational weeks 24 to 28 who underwent 75-g OGTTs were included. Patients were evaluated by dividing them into two groups. Group 1 included 300 women with GDM. Group 2 included 300 healthy pregnant women who were negative on the OGTT test. We retrieved patient ages, gestational weeks, all blood count data derived during pregnancy, fasting blood glucose levels, heights and weights, and body mass indices. Results: Leukocyte and neutrophil counts were significantly higher in the diabetic patient group than in the control group insert ignore into journalissuearticles values(both p < 0.01);. The NLR and PLR differed significantly between the two groups insert ignore into journalissuearticles values(both p < 0.01);, but the demographic data did not. Conclusion: Increase in white blood cell count, and elevations in the PLR and NLR, independently predicted GDM. Blood NLR and PLR can also be used as a GDM screening test. The NLR and PLR insert ignore into journalissuearticles values(markers of inflammation); were significantly increased in pre-diabetic and diabetic patients. The NLR and PLR may usefully predict pre-diabetes and GDM.
Keywords : Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, pregnancy, gestational diabetes