Could Plateletcrıt, in The Fırst 24 Hours of Lıfe, Be an Early Indıcator of Poor Etıology and Prognosıs in Preterm Infants?

Authors : Salar GACHPAZ SARKHIZ, M Yaşar KILINÇ, Saime Sundus UYGUN, Murat KONAK, Hanifi SOYLU

Pages : 176-181

View : 42 | Download : 9

Publication Date : 2019-12-10

Article Type : Conference Paper

Abstract :Platelet indices such as mean platelet volume insert ignore into journalissuearticles values(MPV); and platelet numbers insert ignore into journalissuearticles values(Plt); have been used as predictive indicators in many diseases of preterm infants. However, there is limited data regarding use of plateletcrit insert ignore into journalissuearticles values(PCT); as an indicator of many detrimental conditions insert ignore into journalissuearticles values(ie, gestational diabetes, hypertension and infection); and also clinical conditions such as necrotizing enterocolitis insert ignore into journalissuearticles values(NEC);, sepsis and mortality in preterm neonates. Objective: The aim of this retrospective study was to investigate if PCT in the first 24 hour could indicate above mentioned conditions and predict poor prognosis compared to other blood parameters such as Hemoglobin insert ignore into journalissuearticles values(Hgb);, Mean Corpuscular Volume insert ignore into journalissuearticles values(MCV);, Red Blood Cell Distribution Width insert ignore into journalissuearticles values(RDW);, White Blood Cell insert ignore into journalissuearticles values(WBC);, Plt, MPV and Platelet Distribution Width insert ignore into journalissuearticles values(PDW);. Design/Method: All premature babies ≤ 32 weeks and admitted to NICU of Selcuk University between January 2018 to June 2019 were investigated. Their maternal conditions for gestational hypertension insert ignore into journalissuearticles values(GH);, diabetes and infection during pregnancy were analysed to reveal potential relation between antenatal conditions and postnatal markers. Infants were also reviewed according to their clinical prognosis and presence of intrauterine growth restriction insert ignore into journalissuearticles values(IUGR);, sepsis, NEC and mortality. The first blood parameters insert ignore into journalissuearticles values(Hgb, MCV, RDW, WBC, Plt, MPV, PDW and PCT were recorded and evaluated. Results: Of the 186 infants insert ignore into journalissuearticles values(GW: 29±1weeks, BW: 1300±100 gr);, 92 insert ignore into journalissuearticles values(49.5%); were girls and 94 insert ignore into journalissuearticles values(50.5%); were boys. Mean maternal age was 28 ± 1years and 3.8% of these mothers had gestational diabetes, 10.2% hypertension and 9.7% infection. From baby standpoint, 20 infants insert ignore into journalissuearticles values(10.8%); had IUGR, 50 insert ignore into journalissuearticles values(26.8%); infants had sepsis, and 18 insert ignore into journalissuearticles values(9.6%); infants had NEC. Thirty five infants insert ignore into journalissuearticles values(18.8%); died during hospital course. In term of gender, there was no difference between BW, Mother’s age, although male infants were heavier than females insert ignore into journalissuearticles values(p<0.05);. Hematological parameters were similar between 2 genders insert ignore into journalissuearticles values(p>0.05);. WBC, Plt, RDW parameters were affected from GH. Interestingly MPV was not affected from any antenatal and postnatal conditions, but PCT levels were significantly low in IUGR, sepsis and in mortality group. Although, platelet numbers are closely related with PCT, they were also affected from IUGR. Both sepsis and mortality were found associated with GW and BW. Conclusions: Unlike to many studies showing benefits of MPV as a marker of poor prognosis in preterm babies, our study did not show such a benefit of MPV. On the other hand we found PCT as a good marker for detection of antenatal and postnatal detrimental factors on the newborn babies. We believe that prospective studies are needed to understand value of using PCT in this tiny population.
Keywords : Plateletcrit, preterm babies, marker, prognosis

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