The Effect of Obesity on Metabolic Risk Factors in Children with Urinary Stones

Authors : Sevgin Taner, Kamina Panahli, Asena Ünal, Gunay Ekberli, Orkun Tolunay

Pages : 101-106

View : 72 | Download : 76

Publication Date : 2023-10-15

Article Type : Research Paper

Abstract :Background: Hypercalciuria, hyperoxaluria, hyperuricosuria, hypocitraturia have accepted as metabolic risk factors causing urolithiasis. There are many studies reporting that obesity increases the risk of stone formation by metabolic risk factors. The aim of this study is to evaluate the frequency of metabolic risk factors and the effect of body mass index (BMI) on them. Methods: Children with urolithiasis >3 mm included in the study. Demographic information and biochemistry analyses including urine metabolic screening were recorded. Results: Of the 155 patients (94 male/61 female) included in the study, with a mean age of 71±57 months, 98 (63%) have a family history of stones. There was at least one metabolic risk factor in 38.7% of the patients, and the most common ones were hyperoxaluria (16.8%) and hypocitraturia (16.8%), respectively. The presence of metabolic risk factors was significantly higher in patients with stone size ≥5 mm and with multiple stones, respectively (p=0.015, p=0.028). Patients with underweight and normal weight were grouped as Group 1 (n=99 patients), and those with overweight and obese as Group 2 (n=56 patients). The frequencies of hypercalciuria, hyperuricosuria, hyperoxaluria, hypocitraturia and cystinuria were similar between groups. Conclusion: Family history is common in children with urinary system stones. Since the probability of metabolic risk factors is higher in patients with stone size >5 mm and multiple stones, evaluation in this regard would be appropriate, especially in these patients. There was no evidence in this study that obesity increases metabolic risk factors.
Keywords : ürolitiazis, obezite, vücut kitle indeksi, hiperoksalüri, hipositratüri