Retrospective Investigation of Alcohol Intoxications Followed in Intensive Care Unit

Authors : Bengü Gülhan Köksal, Keziban Bollucuoğlu, Çağdaş Baytar, Rahşan Dilek Okyay, Özcan Pişkin, Gamze Küçükosman, Hilal Ayoğlu

Pages : 144-151

View : 25 | Download : 38

Publication Date : 2024-08-30

Article Type : Research Paper

Abstract :Aim: The majority of alcohol-related deaths are due to acute alcohol consumption. There are many factors affecting the prognosis of alcohol toxicity. It has been reported that by determining these factors, mortality rates can be reduced by early diagnosis and early initiation of treatment. In this study, we aimed to determine the prognosis by evaluating the clinical status and laboratory factors of patients followed up in intensive care unit (ICU) due to acute alcohol intoxication. Materials and Methods: The study included 21 patients with acute alcohol intoxication who were followed up in the ICU of our hospital between 2013-2021.Laboratory parameters, demographic characteristics and clinical status of the patients were recorded. Patients were divided into both exitus and survivors and according to the type of alcohol consumed (ethanol and methanol). Results: All patients were male with a mean age of 40.10 ± 15.9 years. 52.4% of the admissions were ethanol poisoning and 47.6% were methanol poisoning. Mortality rate was 33.3%. It was observed that symptoms appeared later in methanol intoxication compared to ethanol intoxication (p<0.001). When ethanol and methanol groups were compared, pH and HCO3- levels were lower and lactate and creatinine levels were higher in Group M. Advanced age, low Glasgow coma scale (GCS) and Acute Physiology and Chronic Health Evaluation (APACHE II) scores, high neutrophil/lymphocyte ratio (NLR), lactate, anion gap, creatinine, osmolarity and low pH, HCO3- were associated with mortality (p<0.05). Conclusion: In this study, advanced age, low GCS and APACHE scores, metabolic acidosis with high anion gap in laboratory findings, increased NLR, lactate level and creatine elevation were found to be associated with mortality in acute alcohol intoxication. We think that patients with these findings should be followed closely.
Keywords : Etanol, Metanol, İntoksikasyon, Mortalite