Unraveling the Mystery: How High Density Lipoprotein ‘Good’ Cholesterol Goes ‘Bad’?

Authors : Oğuz Arslantürk, Ahmet Aydın, Fatih Gümüş, Kübra Aydın, Dilara Zeybek, Hande Canpınar, Murat Güvener

Pages : 177-184

View : 39 | Download : 42

Publication Date : 2024-08-30

Article Type : Research Paper

Abstract :Background: In recent years, research has highlighted the importance of Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in the progression of atherosclerosis, particularly its interaction with high-density lipoprotein (HDL). Our study aimed to explore the role of dysfunctional High-Density Lipoprotein (HDL) in binding to Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) among patients with Coronary Artery Disease (CAD) and its implications for the advancement of atherosclerosis. Methods: We enrolled twenty-one patients who underwent multivessel CABG using internal mammary artery (IMA), radial artery (RA), and saphenous vein (SV) grafts between November 2019 and April 2020. Using CD31 to identify endothelial cells, we evaluated LOX-1 expression in all cultured cells. Results: Our study comprised 21 patients, including 17 (80.9%) males and 4 (19.04%) females. We observed a significant positive correlation between HDL and LOX-1+ expression in specimens extracted from all types of grafts (SV, r=0.60; RA, r=0.48; IMA, r=0.53). Approximately 28% of the variation in LOX-1+ expression for IMA (F=7.03; p<0.05), 36% for SV (F=10.10; p<0.05), and 24% for RA (F=5.64; p<0.05) was attributed to HDL. Conclusions: Our findings suggest that in cases with heightened LOX-1 receptor expression, HDL binds to LOX-1, leading to a loss of functionality. Monitoring HDL and LOX-1 levels could enhance the prediction of patient responsiveness to treatment and inform appropriate interventions
Keywords : Ateroskleroz, koroner arter bypas greftleri, kardiyovasküler hastalık, lipoprotein