The Relationship Between Platelet Indices, Hormonal Status, and Insulin Resistance in Adolescents with Polycystic Ovary Syndrome: A Retrospective Case-Control Study

Authors : Serap Topkara Sucu, Hüseyin Levent Keskin

Pages : 113-119

View : 46 | Download : 32

Publication Date : 2024-08-30

Article Type : Research Paper

Abstract :Aim: This study aimed to investigate the relationship between polycystic ovary syndrome in adolescents, a disease caused by inflammation and insulin resistance that is associated with metabolic disorders, and platelet indices, which provide information about platelet activity. Materials and methods: Patients with oligoovulation, hyperandrogenemia, or clinical signs of hyperandrogenism (hirsutism, acne, etc.) and polycystic appearance with ≥ 20 small follicles ≥ 2∼ 9 mm in diameter in both ovaries on ultrasound according to the newly updated Rotterdam criteria were included in the study with a diagnosis of polycystic ovary syndrome and formed PCOS group. Patients with similar age groups and body mass index (BMI) values who presented to the clinic for non-PCOS symptoms (vaginitis, dysmenorrhea, cystitis), whose complete blood count was checked during hormone testing, and who did not meet the Rotterdam criteria were selected as the control group. Platelet indices found in routine blood count parameters (platelet large cell ratio (P-LCR), platelet distribution width (PDW) and mean platelet volume (MPV)) were analyzed between the two groups. In addition, the relationship between these indices and hormone status and insulin resistance in PCOS patients was analyzed. Patients with diabetes mellitus, hypertension, malignant diseases, cardiovascular diseases, essential thrombocytopenia or other blood diseases and patients taking medication were excluded. Results: In the study of 123 patients, there was no statistically significant difference between the groups in terms of age and body mass index (p:>0.05). When hemogram parameters were compared between the groups, hemogram parameters such as P-LCR (p: 0.002), PDW (p: 0.011) and MPV (p: 0.007), which indicate platelet activity, were statistically significantly higher in the PCOS group. When the data of PCOS patients were analyzed, platelet indices were found to be higher in the group with high insulin resistance (p: <0.005). When analyzing the hormonal status, only the prolactin level in the blood correlates positively with the values of P-LCR (r:0.223, p: 0.017), PDW (r:0.214, p:0.022), and MPV (r: 0.213, p:0.023). Conclusion: Analyzing platelet indices in routine blood counts of patients with polycystic ovary syndrome, informing patients about their predisposition to metabolic diseases and making the necessary referrals will contribute to the treatment and follow-up of polycystic ovary syndrome. These tests, which can be easily performed in any center, should be used in common practice.
Keywords : Kan Trombositleri, Metabolik Sendrom, Polikistik Over Sendromu