The Effect of the Human Papilloma Virus on the Nuclei and Cellular Structure of Cervical Epithelial Cells; Light Microscopy and Cytomorphological Analysis

Authors : Zehra Safi Öz

Pages : 1-6

View : 33 | Download : 22

Publication Date : 2025-04-30

Article Type : Review Paper

Abstract :The most common sexually transmitted virus is Human papillomavirus (HPV), which comes in more than 280 types The basal cells of epithe lial tissues are responsible for taking up the HPV virus in cases of infection and malignancy caused by the virus. HPV, especially through the E6 and E7 proteins of high-risk HPV types, can cause benign infections or malignancies by inactivating tumor suppressor genes, disrupting cell cycle control, activating telomerase, preventing cell adhesion, polarity and differentiation, suppressing the immune system, and prevent ing apoptosis by inactivating tumor suppressor genes (especially p53, pRb). In this review, the effects of Human papillomavirus on epithelial cells were evaluated in terms of morphological changes and the nucle us-cytoplasm ratio mediated by specific proteins of the virus. Morphological changes are discussed under the headings of koilocytosis, cytoplasmic vacuolization, nuclear enlargement, nuclear membrane irregularities, hyperchromasia, abnormal chromatin distribution, micro nucleation, binucleation, karyorrhexis, karyolysis karyopyknosis and nuclear budding. Nuclear architecture changes, which play a crucial role in gene regulation, are particularly prominent. Finally, it is believed that knowledge of the changes that HPV causes in cell nuclear and cytoplasmic texture will facilitate the development of a cost-effective and appropriate approach to explaining cervical cancer pathophysiology, the development of specific biomarkers, and the development of new perspectives in understanding HPV\\\'s impact on cancer.
Keywords : İnsan papilloma virus, İPV, serviks kanseri, sitoloji, skuamöz epithel hücre, PAP simir