Proton Transfer Salt and Metal Complexes of 4,4`-Ethylenedipyridine and 2,3-Pyrazinedicarboxylic Acid: Synthesis, Structural Characterization and Biological Activity

Authors : Nurgün Büyükkıdan, Seher Kaya, Halil İlkimen, Aysel Gülbandılar

Pages : 103-113

Doi:10.55117/bufbd.1579652

View : 31 | Download : 56

Publication Date : 2024-12-31

Article Type : Research Paper

Abstract :In this study, a new salt {(H2BPE)(PDA), 1} synthesized from 4,4’-ethylenedipyridine (BPE) with 2,3 pyrazinedicarboxylic acid (H2PDA) and its complexes Fe(III) {(H2BPE)[Fe2(PDA)(H2O)4]n, 2} and Ni(II) {[Ni(PDA)(BPE)2(H2O)2]n.H2O, 3}, were synthesized and defined by using 1H and 13C NMR, TG-DTA, IR, UV Vis, elemental analysis, magnetic susceptibility techniques. In addition, antibacterial and antifungal activities of starting materials and synthesized compounds against Candida albicans yeast and Bacillus subtilis, Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli and Listeria monocytogenes bacteria were investigated using the microdilution method and compared with existing antibiotics (Cefepime, Vancomycin, Levofloxacin and Fluconazole). Compounds 1-3 were observed to have activity against yeast and bacteria. In particular, compound 3 (7.80 µg/mL) against E. faecalis, compounds 3 (7.80 µg/mL) against B. subtilis bacteria, and compound 1 (15.60 µg/mL) against C. albicans yeast. showed better activity than control compounds.
Keywords : 4, 4\'-Etilenedipiridin, 2, 3-Pirazin dikarboksilik asit, Metal kompleksi, Antimikrobiyal aktivite