Antioxidant and Antibacterial Activities of Salen-type Schiff Base and Metal Complexes

Authors : Sezer GÖYCINCIK, Hatice DANAHALİLOĞLU

Pages : 329-336

Doi:10.17798/bitlisfen.1185118

View : 23 | Download : 24

Publication Date : 2023-06-27

Article Type : Research Paper

Abstract :2-Aminobenzylamine based unsymmetrical salen type Schiff base and its Cuinsert ignore into journalissuearticles values(II);, Niinsert ignore into journalissuearticles values(II);,Coinsert ignore into journalissuearticles values(II); and Feinsert ignore into journalissuearticles values(III); metal complexes were researched in terms of their antioxidant and antibacterial activities in this study. 1,1-Diphenyl-2-picrylhydrazyl radical scavenging insert ignore into journalissuearticles values(DPPH); method, ferric reducing antioxidant power insert ignore into journalissuearticles values(FRAP); method and cupric reducing antioxidant capacity insert ignore into journalissuearticles values(CUPRAC); method were carried out for determination of antioxidant effects of compounds. The antioxidant activity of the compounds were compared with the standard antioxidants butylated hydroxyanisole insert ignore into journalissuearticles values(BHA); and butylated hydroxytoluene insert ignore into journalissuearticles values(BHT);. Fe, Ni and Cu complexes exhibited more scavenging activity than BHT. All compounds exhibit lower ferric reducing activity than BHA and BHT. Fe complex, Ni complex and the ligand have more antioxidant capacity than corresponding to BHT according to CUPRAC method. These assays showed that all compounds researched can use as synthetic antioxidants. Antibacterial effects of Schiff base and its metal complexes were investigated by agar disc diffusion method. Antibacterial studies of the compounds were achieved against some gram-positive and gram-negative bacteria. Enterococcus faecium, Pseudomonas aeroginosa, Klebsiella pneumoniae and Escherichia coli were used as bacterial strains. The beneficial datas were acquired.
Keywords : Salen type Schiff base, Metal complexes, FRAP, DPPH, CUPRAC, Antibacterial activity