Investigation of Antibiotic Resistance Rates of Bacteria Causing Urinary System Infection

Authors : Fatih Mehmet Akıllı, Beste Akıllı, Bilgehan Ergan
Pages : 155-161
Doi:10.16919/bozoktip.1572362
View : 29 | Download : 34
Publication Date : 2025-06-15
Article Type : Research Paper
Abstract :Urinary tract infection(UTI) is a prevalent health concern globally. The objective of this project was to evaluate the frequencies of pathogens associated with UTI and their antimicrobial susceptibility patterns, as well as extended-spectrum beta-lactamase(ESBL) rates. Urine culture results between January 2023 and December 2023 were examined retrospectively. Additionally, variables such as age, sex, and medical department were documented. The study included patients aged 18 years or above with pathogenic bacterial growth in their urine cultures. The identification of bacteria and their antibiotic susceptibility was conducted using conventional methods or the VITEK2-Compact system. Of 3135 urine samples considered to be causative agents were evaluated. 2495 Escherichia coli, 404 Klebsiella spp., 117 Proteus mirabilis, 57 Pseudomonas spp., 19 Acinetobacter spp., and 43 other enterobacterales members were detected. ESBL positivity rates were found to be for E. coli 14.9% and for Klebsiella spp. 23.2%. Resistance rates of hospital-acquired infection agents were found to be significantly higher than community-acquired. More than 90% susceptibility to carbapenems and aminoglycosides has been detected. It is beneficial to be aware of the evolution of antibiotic resistance over time, particularly when embarking on empirical therapy. The elevated level of quinolone resistance in hospital-acquired infections can be attributed to its utilisation for a multitude of indications, including pneumonia, gastroenteritis, and urinary tract infections. Our findings indicate that ciprofloxacin, trimethoprim-sulfamethoxazole, and ampicillin are unsuitable for the empirical treatment of UTIs, while nitrofurantoin and fosfomycin represent rational options. We believe that these data will shed light on empirical treatments in our hospital.
Keywords : Escherichia coli, İdrar yolu enfeksiyonları, Antibiyotikler, Klebsiella spp, GSBL

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