THIOL-DISULFIDE HOMEOSTASIS IN MYASTHENIA GRAVIS

Mariam Kavakcı; Merve Okuyucu; Salim Neşelioğlu; Evren Yaşar; Özcan Erel

doi:10.16919/bozoktip.1716368

THIOL-DISULFIDE HOMEOSTASIS IN MYASTHENIA GRAVIS

Authors : Mariam Kavakcı, Merve Okuyucu, Salim Neşelioğlu, Evren Yaşar, Özcan Erel

Pages : 324-330

Doi:10.16919/bozoktip.1716368

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Publication Date : 2025-09-15

Article Type : Research Paper

Abstract :Objective: Neuromuscular junction disorders (NJD), characterized by a dysfunction in neuromuscular transmission, may be associated with oxidative stress. This study aimed to evaluate the role of thiol-disulfide homeostasis as an index of oxidative stress in adult patients with NJD (i.e., myasthenia gravis) compared to healthy controls, considering its potential as a biomarker and therapeutic target. Materials and Methods: This study included 46 patients with myasthenia gravis and 46 age- and gender-matched healthy controls. Blood samples were collected and analyzed for thiol-disulfide homeostasis parameters, total antioxidant status (TAS), and ischemia-modified albumin (IMA) using spectrophotometric and colorimetric methods. Statistical analysis was conducted using SPSS to compare the groups and examine correlations between oxidative and antioxidant markers. Results: Patients showed significantly lower levels of native thiol, total thiol, and TAS, and higher levels of disulfide, disulfide/native thiol percentage ratio, and IMA compared to controls (p<0.05 for all). These findings indicate increased oxidative stress and disrupted antioxidant defense in patients with myasthenia gravis. There were also significant correlations between decreased antioxidant parameters and increased oxidative stress markers. Conclusion: This study confirms that thiol-disulfide homeostasis is significantly altered in patients with myasthenia gravis, highlighting its potential role as a biomarker for disease pathogenesis and a target for therapeutic intervention. Future research could expand on these findings to develop targeted therapies aimed at restoring redox balance in patients with NJD.
Keywords : tiyol, disülfit, homeostazi, nöromusküler, myastenia gravis

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