Evaluation of the relationship between serum YKL-40, HMGB1, BDNF, NGF levels, and cognitive functions in patients undergoing coronary artery bypass grafting

Authors : Başak Koçak, Erkan İriz, Sureyya Barun, Özlem Gülbahar Zengin, Mustafa Arslan

Pages : 374-381

Doi:10.16919/bozoktip.1597904

View : 92 | Download : 155

Publication Date : 2025-12-15

Article Type : Research Paper

Abstract :ABSTRACT Objective: Postoperative cognitive dysfunction (POCD) is characterized by symptoms that may inhibit planning, such as dementia, memory loss, attention deficiency, and behavioral impairment. Although it is frequently in cardiac surgery, all manner of surgery can cause POCD. In this manuscript, we aimed to show the existence of a correlation among neuroinflammation markers High-mobility group box 1 (HMGB1) and YKL-40 and neurotrophic factors; brain-derived neurotrophic factor (BDNF) and Nerve growth factor (NGF), with the cognitive functions. Material and methods: Twenty-four patients who underwent coronary artery bypass graft (CABG) were analyzed prospectively. Preoperative 2nd and postoperative 5-7th day blood samples were collected, and we performed cognitive test synchronously. Correlations between YKL-40, BDNF, NGF, HMGB1, and cognitive test score (CTS) were examined. Results: We found a significant postoperative decrease in NGF (p=0.006). There was a positive correlation between NGF and postoperative CTS (r=0.542, p=0.006). Postoperative memory score was increased (p<0.0001), but orientation and vigilance scores were decreased (p=0.032 and p=0.022, respectively). There were also self-reliant positive correlations between preoperative and postoperative CTS (r=0.825, p <0.0001), preoperative and postoperative HMGB1 (r=0.529, p=0.008) and preoperative and postoperative NGF scores (r=0.454, p=0.026). Postoperative CTS had a negative correlation with age (r=-0.447, p=0.029), duration of operation (r=-0.506, p=0.012), and cardiopulmonary bypass (CPB) (r=-0.403, p=0.039). Conclusion: Data in this study suggested that NGF can be a notable parameter in POCD, and HMGB1 may be a crucial marker in heart disorders. To define appropriate diagnosis and treatment strategies, it is essential to detail the relationship between cognitive functions, neuroinflammation, and neurotrophic factors.
Keywords : Koroner arter bypass greft, NGF, postoperatif komplikasyon, kognisyon

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