Comparative Analysis of CBC-Derived Inflammatory Biomarkers in Optic Neuritis and Non-Arteritic Anterior Ischemic Optic Neuropathy

Meryem Tuba Sönmez; Selda Çelik Dülger; Duygu Arslan Mehdiyev; Hikmet Saçmacı; Funda Uysal Tan

doi:10.16919/bozoktip.1758887

Comparative Analysis of CBC-Derived Inflammatory Biomarkers in Optic Neuritis and Non-Arteritic Anterior Ischemic Optic Neuropathy

Authors : Meryem Tuba Sönmez, Selda Çelik Dülger, Duygu Arslan Mehdiyev, Hikmet Saçmacı, Funda Uysal Tan

Pages : 448-458

Doi:10.16919/bozoktip.1758887

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Publication Date : 2025-12-15

Article Type : Research Paper

Abstract :Objective: Demyelinating optic neuritis (ON) and non-arteritic anterior ischemic optic neuropathy (NAION) represent distinct clinical entities with different pathophysiological mechanisms, yet both are believed to involve systemic inflammatory responses. This study aimed to compare systemic inflammatory indices derived from complete blood count (CBC), including the systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and pan-immune-inflammation value (PIV), in patients with ON and NAION. Material and Methods: Inflammatory indices (SII, SIRI, PIV, NLR, PLR, and MLR) were calculated using CBC parameters obtained before corticosteroid treatment. A total of 18 patients with demyelinating ON and 25 with NAION were included, along with age- and sex-matched healthy control groups (16 for ON, 11 for NAION). ROC analyses were performed for SII and PIV in the NAION group to assess diagnostic performance. Results: SII (p = 0.015), PIV (p = 0.004), and SIRI (p = 0.001) were significantly elevated in the NAION group compared to controls. ROC analyses demonstrated AUC values of 70.1% for SII and 73.8% for PIV, indicating moderate diagnostic utility in distinguishing NAION. No significant differences in these indices were observed between the ON group and their respective controls. In the direct comparison between disease groups, patients with NAION exhibited higher SIRI and monocyte levels than those with ON. Conclusions: Composite inflammatory indices derived from CBC, particularly SII, SIRI, and PIV, were significantly elevated in patients with NAION. These findings support the role of systemic inflammation in NAION pathophysiology and highlight the potential diagnostic and prognostic value of these indices. Further prospective studies with larger cohorts are warranted to validate their clinical relevance.
Keywords : Optik nörit, non-arteritik anterior iskemik optik nöropati, tam kan sayımı, sistemik inflamasyon, SII, SIRI, PIV

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