Retrospective evaluation of COVID-19 incidence during smoking cessation treatment with varenicline

Authors : Elif Barış, Gökçen Ömeroğlu Şimşek, Aylin Arici, Mukaddes Gümüştekin, Oğuz Kılınç, Metiner Tosun

Pages : 30-35

Doi:10.34087/cbusbed.1276244

View : 71 | Download : 91

Publication Date : 2024-03-27

Article Type : Research Paper

Abstract :Background: Cholinergic anti-inflammatory pathway endogenously controls inflammatory processes through activation of the α7-nicotinic acetylcholine receptor (α7nAChR). Varenicline, used in smoking cessation therapy, is a full α7nAChR agonist with anti-inflammatory effects. In this study, the frequency of coronavirus disease (COVID-19) was evaluated in patients using varenicline as a smoking cessation treatment. Methods: In this retrospective cross-sectional study, records of the 111 patients admitted to Smoking Cessation Outpatient Clinic of Dokuz Eylul University Faculty of Medicine during the COVID-19 pandemic were evaluated. The development of COVID-19 disease according to the status of the patients being positive for SARS-COV-2 was evaluated comparatively in patients who received varenicline or not. Additionally, the disease symptoms were questioned. Results: SARS-CoV-2 PCR positivity was not detected in any of 38 patients who regularly used varenicline out of 68 patients evaluated. SARS-CoV-2 PCR positivity was detected in 13 (43.3%) of 30 patients who received other treatments or irregularly used varenicline (p<0.001). Conclusions: Patients under smoking cessation treatment did not develop COVID-19 during the period of varenicline use compared to non-users suggesting that the medication may have a protective role in the development of COVID-19 which might be further investigated by clinical trials.
Keywords : COVID 19, SARS CoV 2, Retrospektif Araştırma, Sigara Bırakma Tedavisi, Vareniklin