The Effect Of Serotonın Reuptake Inhıbıtor Use On Restless Legs Syndrome In Chıldren

Authors : Derya Yavuz Demiray, Seda Aybüke Sarı, Mehmet Erdem

Pages : 110-116

Doi:10.34087/cbusbed.1627593

View : 18 | Download : 21

Publication Date : 2025-03-26

Article Type : Research Paper

Abstract :Objective: This research intends to investigate the relationship between selective serotonin reuptake inhibitors (SSRIs) and the occurrence rate of Restless Legs Syndrome (RLS) among pediatric and adolescent populations diagnosed with depression and/or anxiety disorders. Materials and Methods: This retrospective study examined patients between the ages of 10 and 17 who had been prescribed one of the following selective serotonin reuptake inhibitors (SSRIs): fluoxetine, sertraline, or escitalopram. Exclusion criteria included patients with iron deficiency anemia, diabetes mellitus, renal disorders, spinal cord conditions, those receiving antihistaminic or antipsychotic medications, and individuals with other psychiatric or neurological disorders. The study meticulously recorded demographic information, medical histories, ferritin levels, vitamin B12 levels, and a family history of restless legs syndrome (RLS). Furthermore, the severity of RLS was evaluated using a specific scale for patients diagnosed with the condition. Results: Among the 40 children analyzed, 10% developed RLS. The results indicated a potential link between SSRI use and the onset of RLS symptoms. No significant relationship was found between RLS and hemoglobin, ferritin, or vitamin B12 levels. Half of the RLS patients had a family history of RLS. Conclusion: The results indicate a possible association between the administration of SSRIs and the emergence of RLS in pediatric and adolescent populations. It is advisable to conduct additional studies with an expanded sample size.
Keywords : Huzursuz bacak sendromu, çocuklar, serotonin gerialım inhibitörleri, depresyon, anksiyete bozuklukları