Effects of propofol, desflurane and isoflurane on perioperative blood glucose level in intracranial mass operation: A randomized controlled trial

Authors : Yonca Özvardar PEKCAN, Atilla ŞENCAN, Kaan KATIRCIOĞLU, Murat AKSUN, Hüseyin Serdar SAVACI

Pages : 41-47

View : 15 | Download : 25

Publication Date : 2021-03-04

Article Type : Research Paper

Abstract :The aim of this study is to compare the effects of the propofol, desflurane and isoflurane on blood glucose levels in cranial surgery. Ninety, ASA I-II patients aged between 18-60 years old were scheduled for study. Induction was performed with fentanyl, propofol and cisatracurium in all patients. Anaesthesia was maintained using propofol 4-6 mg/kg/h in propofol group insert ignore into journalissuearticles values(Group P);, desflurane and isoflurane 0.5-1 MAC in group desflurane insert ignore into journalissuearticles values(Group D); and group isoflurane insert ignore into journalissuearticles values(Group I);. Remifentanil infusion was applied 0.5 µg/kg/min in all groups. Plasma glucose insert ignore into journalissuearticles values(PG); levels, systolic arterial pressure insert ignore into journalissuearticles values(SAP);, diastolic arterial pressure, mean arterial pressure and heart rate measured. In the 1st, 2nd and 5th hour, PG levels were significantly lower in group P than group D. In the 2nd and 3rd hour, PG levels were significantly lower in group P than group I insert ignore into journalissuearticles values(p <0.05);. In addition, SAP values in group D were found to be significantly lower than group P and group I. With this study, it was concluded that total intravenous anesthesia with propofol infusion in intracranial mass surgery is more effective than inhalation anesthesia such as desflurane and isoflurane in preventing the hyperglycemic response caused by surgical stress
Keywords : Blood glucose level, brain neoplasms, intravenous anethesia