Evaluation of the Complete Blood Count Parameters as Prognostic Markers for Remission of Graves’ Disease with Medical Therapy in Children

Authors : Diğdem BEZEN, Eren VURGUN

Pages : 165-170

Doi:10.26650/jchild.2023.1270111

View : 55 | Download : 46

Publication Date : 2023-06-30

Article Type : Research Paper

Abstract :Objective: Graves’ Disease insert ignore into journalissuearticles values(GD); is an autoimmune disease that causes hyperthyroidism. This study intended to find out whether leukocyte, neutrophil, lymphocyte, platelet counts, and neutrophil-to-lymphocyte ratio insert ignore into journalissuearticles values(NLR); and systemic immun-inflammation index insert ignore into journalissuearticles values(SII); have an association with the remission of GD. Material and Methods: Thirty-seven children who have GD have been included in the study. Anthropometric measurements, physical examination and medical history of patients were recorded. Leukocyte, neutrophil, lymphocyte, platelet counts, NLR and SII at the time of diagnosis and at the end of medical therapy were compared between patients in remission insert ignore into journalissuearticles values(group 1); and patients not in remission insert ignore into journalissuearticles values(group 2);. Results: The rate of patients in remission was 54%. The presence of palpitation was higher in group 2 than group 1 insert ignore into journalissuearticles values(p=0.026);. At the time of diagnosis, the leukocyte and neutrophil counts were higher in group 1 insert ignore into journalissuearticles values(p=0.001 and p=0.014, respectively);. While the absence of palpitation increased the rate of remission 6.0 insert ignore into journalissuearticles values(95% CI: 1.1-33.1); times, the rate of remission increased 2.4 insert ignore into journalissuearticles values(95% CI: 1.1-5.2); times as the neutrophil count increased insert ignore into journalissuearticles values(p=0.041 and p=0.031, respectively);. In group 2, there was an increase in leukocyte and neutrophil counts, NLR and SII after medical therapy compared to the levels at the time of diagnosis insert ignore into journalissuearticles values(p=0.049, p=0.008, p=0.002 and p=0.001, respectively);. Conclusion: Presence of palpitation and lower neutrophil count at the time of diagnosis and increase in leukocyte count, neutrophil count, NLR and SII levels after medical therapy could be prognostic markers for not achieving remission with medical therapy of GD in children.
Keywords : Graves Hastaliği, Çocuklar, Remisyon, Prognostik Belirteçler, Nötrofil Lenfosit Orani, Sistemik Immün Enflamasyon Indeksi

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