The Relationship Between Hypothyroidism-Induced Autoantibodies, TSH Levels, and RDW, as an Inflammation Marker

Authors : Kemal AYGÜN, Ozden GOKDEMIR, Ali Rıza ŞİŞMAN, Tevfik DEMİR

Pages : 56-66

Doi:10.36516/jocass.1210920

View : 31 | Download : 11

Publication Date : 2023-04-30

Article Type : Research Paper

Abstract :Aim: Serum RDW grades were detected in patients with Hashimoto\`s thyroiditis. We aimed to use RDW to detect increased cardiovascular events in patients, increased oxidative stress, and inflammation without the need for an additional cost. Methods: We collected 904 persons results, 462 patients which have Hashimoto\`s thyroiditis, and 442 age and sex-matched control cases were comprised in our study. From laboratory measurements of the patients’ records were utilized such as hemogram, hs-CRP, fasting blood glucose, insulin, C-peptide, kidney function tests, liver function tests insert ignore into journalissuearticles values(ALT, AST);, serum lipids insert ignore into journalissuearticles values(total cholesterol, triglyceride, HDL, LDL);, anti-Tg, and anti-TPO, FT3, FT4, TSH levels. Results: RDW was considerably scaled up in case group compared to control group insert ignore into journalissuearticles values(Hashimoto\`s thyroiditis =10.08 ± 4.48%, control = 8.95 ± 6.68%, p <0.05);. Also, MPV was increased in the study groupinsert ignore into journalissuearticles values(p<0.05);. hs-CRP showed a statistically significant positive correlation between the level of RDW. Conclusion: Although the exact mechanism is still not fully understood, increased RDW levels in individuals with Hashimoto’s thyroiditis, possibly related to ongoing subclinical inflammation, neurohumoral activation, and changes resulting from oxidative stress in such patients. RDW is potentially a valuable tool for assessing cardiovascular diseases among patients diagnosed with Hashimoto\`s thyroiditis.
Keywords : RDW, Hashimoto, MPV, inflammation, hs CRP, thyroid auto antibodies

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