Effects of Antidepressant Agents on Cornea and Ocular Surface

Authors : Ömer ÖZER, Emin Serbülent GÜÇLÜ

Pages : 124-129

View : 30 | Download : 9

Publication Date : 2023-04-30

Article Type : Research Paper

Abstract :Aim: Today, antidepressants, which are frequently prescribed by physicians for different purposes, have various effects on ocular tissues. The aim of this study is to evaluate the effects of different agents on the cornea and ocular surface. Material-Methods: For this purpose, 50 healthy controls and 336 patients were included in this study. Results: Compared to the control group, all patient groups had higher OSDI scores and staining scores, and a lower Schirmer test result and a lower tear break-up time insert ignore into journalissuearticles values(all parameters, p<0,001);. When specular microscope data were evaluated, cell density and hexagonality were found to be lower in all patient groups compared to the control group insert ignore into journalissuearticles values(all parameters, p<0,001);. In the corneal topography data, there was a significant difference in all parameters in the patient groups when compared to the control group insert ignore into journalissuearticles values(all parameters, p<0,001);. Conclusion: In conclusion, all antidepressant agents, especially sertraline and escitalopram in the SSRI group, have adverse effects on the cornea and ocular surface. Among the current treatment options, agents in the SNRI group are more compatible with the ocular surface.
Keywords : Antidepresan, İlaçlar, Kornea, Oküler yüzey, Toksikoloji

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