Effectiveness of Boric Acid in Preventing Acrylamide-Conducted Brain Damage in Rats

Authors : Eda YİLDİZHAN, Burak Veli ÜLGER, Ercan GÜNDÜZ, Murat AKKUŞ, Hüseyin BİLGE
Pages : 92-97
Doi:10.36516/jocass.1239256
View : 35 | Download : 12
Publication Date : 2023-04-30
Article Type : Research Paper
Abstract :Aim: Acrylamide insert ignore into journalissuearticles values(ACR); is a water-soluble neurotoxic substance that has been widely researched in recent years. Boric acid insert ignore into journalissuearticles values(BA); is a component that does not have a toxic effect when taken at low concentrations and has a cystotoxic activity. Studies have reported that BA has antioxidant effects. In this study, we aimed to examine the protective efficacy of BA against the toxic damage that ACR may cause in the brain tissue. Material: In this study, 28 Wistar Albino male rats with an average weight of 320-400 grams were used. In our study, ACR was administered intraperitoneally insert ignore into journalissuearticles values(i.p.); at a dose of 50 mg/kg for 14 days, while BA was administered orally insert ignore into journalissuearticles values(p.o.); with a dose of 200 mg/kg for 14 days. Group 1 insert ignore into journalissuearticles values(n=7);: It is the control group and no medication was administered for 14 days. Group 2 insert ignore into journalissuearticles values(n=7);: ACR group, Group 3 insert ignore into journalissuearticles values(n=7);: BA group and Group 4 insert ignore into journalissuearticles values(n=7);: ACR + BA group. Results: The comparison between the groups in terms of serum Total Oxidant Status insert ignore into journalissuearticles values(TOS); and Malondialdehyde insert ignore into journalissuearticles values(MDA); analysis revealed that the highest MDA level was in the ACR group. The MDA and TOS levels of the ACR+BA group were significantly lower than the ACR group insert ignore into journalissuearticles values(p<0.05);. Conclusions: Our study revealed that BA has a protective effect in the prevention of neurotoxicity due to oxidative stress after ACR application.
Keywords : Akrilamid, Borik asit, Oksidatif Stres

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