Protective Effect of Taxifolin in The Prevention of Cardiac Tissue Damage in Liver Ischemia and Reperfusion Injury: Experimental Study

Authors : Hüseyin BİLGE, İbrahim YILDIZHAN, Burak Veli ÜLGER, Ulaş ADAY, Ömer BAŞOL, Kadriye ÇİÇEKÇİ, Eda YİLDİZHAN

Pages : 272-275

Doi:10.36516/jocass.1300968

View : 121 | Download : 80

Publication Date : 2023-08-31

Article Type : Research Paper

Abstract :Aim: Liver ischemia and reperfusion insert ignore into journalissuearticles values(I/R); is a serious, irreversible health problem in clinical practice. Taxifolin insert ignore into journalissuearticles values(Tax); is an easy to obtain and use agent found in maritime pine bark, Douglas fir bark and Siberian larch wood. In this study, we examined the protective efficacy of Taxifolin in the correction of cardiac tissue damage that may develop in liver I/R damage. Methods: In our study, a total of 28 Wistar Albino rats, 8-10 weeks old, weighing 250-300 grams, were used. Group 1 insert ignore into journalissuearticles values(n=7);: control group, Group 2 insert ignore into journalissuearticles values(n=7);: Tax group with 50 mg/kg dose orally for 3 weeks, Group 3 insert ignore into journalissuearticles values(n=7);: Liver I/R group for 30 minutes ischemia and 120 minutes of reperfusion were performed. Group 4 insert ignore into journalissuearticles values(n=7);: Tax+Liver I/R group. Results: In our study, MDA analysis was performed to evaluate oxidative stress. In the statistical analysis of MDA values, we observed that there was a statistically significant difference between the serum MDA values of the Tax group and the Tax+Liver I/R group, and the MDA level of the Tax group was lower insert ignore into journalissuearticles values(p<0.05);. In myocyte damage scoring, we observed that the liver I/R group had the highest damage score, while the damage score of the Tax+Liver I/R group was significantly lower than the I/R group insert ignore into journalissuearticles values(p<0.05);. Conclusion: As a result of our study, we observed that there was an increase in serum MDA levels as a result of liver I/R and histopathological changes occurred in the heart tissue. However, Taxifolin has been successful in ameliorating this situation.
Keywords : Taksifolin, Oksidatif Stres, Karaciğer iskemi ve reperfüzyon, Kalp

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