Hypomagnesemia and Calcineurin Inhibitors in Kidney Transplant Recipients

Authors : Engin ONAN, Saime PAYDAS, Mustafa BALAL, Nebi Cankat GEYGEL, İbrahim AKKAYA, Erhan TATAR

Pages : 327-331

Doi:10.36516/jocass.1317894

View : 41 | Download : 47

Publication Date : 2023-08-31

Article Type : Research Paper

Abstract :Aim: Post-transplant hypomagnesemia is a frequently encountered and significant electrolyte disorder and is more common in patients using calcineurin inhibitors insert ignore into journalissuearticles values(CNIs);. This study aimed to evaluate the frequency of hypomagnesemia and accompanying conditions in the outpatient follow-up of renal transplant recipients. Methods: This cross-sectional study included 236 renal transplant patients. Demographic characteristics of the patients and their biochemical values, including drug levels, were recorded. Results: Of the patients, 69 insert ignore into journalissuearticles values(29.2%); were female, and 194 insert ignore into journalissuearticles values(82.3%); were living donor recipients. The mean age of the entire group was 43.1 years. The frequency of hypomagnesemia was 40% insert ignore into journalissuearticles values(10/25); in the first 12 months, 26.1% insert ignore into journalissuearticles values(23/88); between the 12th and 60th months, 26% insert ignore into journalissuearticles values(32/123); after 60 months, and 27.5% insert ignore into journalissuearticles values(65/236); in all patients. In patients with higher levels of tacrolimus compared to those with the target level, the frequency of hypomagnesemia increased in those with a posttransplant period of 12-60 months insert ignore into journalissuearticles values(40.9% vs. 20.8%, p: 0.018); and over 60 months insert ignore into journalissuearticles values(44% vs. 26%, p: 0.046);. In addition, the magnesium insert ignore into journalissuearticles values(Mg+2); level was lower in patients using tacrolimus compared to those using cyclosporine insert ignore into journalissuearticles values(CsA); insert ignore into journalissuearticles values(1.80±0.18 vs 1.91±0.25, p: 0.003);. The effect of hypomagnesemia on graft functions was statistically insignificant in all groups. Conclusion: Hypomagnesemia is a common electrolyte disorder in the early and late periods after transplantation. In our study, hypomagnesemia did not differ according to proton pump inhibitor insert ignore into journalissuearticles values(PPI); use, gender, fasting blood glucose, and glomerular filtration rate. However, the frequency increased in patients using tacrolimus and those with above-target serum tacrolimus levels.
Keywords : Hipomagnezemi, böbrek nakli, kalsinörin inhibitörü, nakil sonrası elektrolit bozuklukları

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