The Effect of Hyperuricemia and Allopurinol Treatment Outcome of Greft in Kidney Transplant Recipients

Authors : Saime Paydas, Neşat Yücel, Ersin Nazlican, Ilker Unal

Pages : 483-487

Doi:10.36516/jocass.1320561

View : 89 | Download : 49

Publication Date : 2023-12-31

Article Type : Research Paper

Abstract :Introduction: Kidney transplant recipients(KTRs) may have high level of serum uric acid(SUA) due to greft dysfunction and immunosuppressives. In this study, we evaluated effect of high SUA levels and allopurinol therapy in KTRs on renal functions. Patients and Methods: 113 of 233 KTRs had elevated SUA level(G1). Fiftyseven of G1 received allopurinol treatment(G1A+) and 56 patients G1A-) did not. 56 of 118 patients who were followed for five years(G5) were hyperuricemic(G5-1) and 26 of G5-1 treated with allopurinol(G5-1A+) and 30 of them did not(G5-1A-). 62 patients were normourisemic(G5-2). GFR<10 ml/min was considered as graft loss. Results: Of the 233 patients the mean age was 42.8±11.6(17-76), 164 were male(70.0%). In 2.year graft loss developed in 9(7.5 %) and 18(15.9%) of G2 and G1 respectively(p=0.045). According to allopurinol therapy 10 of the graft loss occurred in the G1A+ and 8 in the G1A-(p=0,330). Graft loss occurred in 12(21%) and 9(14%) in G5-1 and G5-2 respectively(p=0.62). Graft loss occurred in 7(23%) and 5(19%) in G5-1A+ and G5-1A- respectively(p=0.71). Considering the first two years graft loss in G5-1 was higher than in the G5-2(p=0.023), and higher SUA levels increased the graft loss by 3.6 times compared to normal SUA levels(95% confidence interval(1,2-12.70). Conclusion: There was a significant relationship between high SUA levels and graf loss in KTRs in 2 years and 5 years. Treatment of high SUA with alIopurinol therapy had protective effect on renal functions. So that tretment of hyperuricemia such as allopurinol can be good option to preserve kidney function in KTRs.
Keywords : Ürik asit, böbrek nakli alıcısı, böbrek fonksiyon bozukluğu, allopurinol

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