Coadministration of Novel Analgesic Isovaline with Tramadol Reduces Inflammatory Pain Response in Rats

Authors : Gözen Öksüz, Tufan Mert, Selma Yaman, Mahmut Arslan, Metin Kılınç, Nurten Seringeç Akkeçeci
Pages : 52-58
Doi:10.36516/jocass.1232464
View : 63 | Download : 78
Publication Date : 2024-06-30
Article Type : Research Paper
Abstract :Aim: Isovaline is a new and promising analgesic with an antinociceptive effect and, unlike µ-opioid agonists, interacts with aminobutyric acid receptors without causing sedation or respiratory depression. In this study, we compare the effect on thermal hyperalgesia and mechanical allodynia coadministration of subcutaneous isovaline and tramadol with individual administrations in a carrageenan-induced hind paw inflammatory pain model in rats. Methods: In this study, isovaline, tramadol, and the combination of isovaline and tramadol were subcutaneously administered to rats with carrageenan-induced inflammation of the hind paws. Hyperalgesia in response to thermal stimuli and allodynia in response to mechanic stimuli were assessed by using a thermal plantar test and a dynamic plantar aesthesiometer, respectively. Results: The administration of subcutaneous isovaline 400mg/kg and tramadol 4mg/ kg combination effect was higher than the other groups on latencies and thresholds (P<0.01). Additionally, isovaline 400 mg/kg administration caused a statistical difference in latencies when compared with carrageenan, isovaline 2mg/kg, and tramadol 2mg/kg groups (P <0.005) and a statistical difference in thresholds when compared with carrageenan, tramadol 2mg/kg and tramadol 4 mg/kg groups (P <0.01). When isovaline 200 mg was used in combination with tramadol 2mg/kg, the latencies and thresholds were significantly higher than either treatment alone tramadol 2mg/kg and carrageenan groups (P≤ 0.001). Conclusions: The results of this study demonstrated that the subcutaneous administration of isovaline had analgesic efficacy and was effective in combination with tramadol when used for the treatment of inflammatory pain.
Keywords : İnflamatuar ağrı, izovalin, tramadol, pençe ödemi

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