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- Serum Uric Acid Predicts Contrast-Induced Nephropathy in Chronic Total Occlusion PCI
Serum Uric Acid Predicts Contrast-Induced Nephropathy in Chronic Total Occlusion PCI
Authors : Fethullah Kayan, Mehmet Zülkif Karahan
Pages : 695-702
Doi:10.5798/dicletip.1840647
View : 46 | Download : 66
Publication Date : 2025-12-12
Article Type : Research Paper
Abstract :Objective: CIN is a significant complication after PCI for CTO. Elevated SUA levels have been implicated in renal injury, but their predictive value for CIN in CTO-PCI patients remains unclear. The present investigation sought to examine the link between SUA levels and CIN risk in this population. Methods: This retrospective observational study included 225 patients with CTO undergoing PCI at Diyarbakır Gazi Yaşargil Training and Research Hospital from April 2017 to March 2023. Patients were partitioned into three groups based on baseline SUA levels: ≤5.2 mg/dL (n=75), 5.3–6.6 mg/dL (n=75), and ≥6.7 mg/dL (n=75). CIN was defined as a >25% increase in serum creatinine within 48–72 hours post-PCI. Clinical, demographic, and laboratory parameters were compared using chi-square, ANOVA, or Kruskal-Wallis tests. Logistic regression analyses and ROC analyses wereperformed to determine SUA’s predictive value for CIN. Results: CIN occurred in 44 patients (19.6%). Higher SUA levels were associated with increased CIN incidence (p<0.001), higher chronic kidney disease prevalence (p<0.001), lower ejection fraction(EF) (p=0.027), and increased mortality (p=0.023). ROC analysis identified a SUA cutoff of 5.95 mg/dL (AUC=0.643, 95% CI: 0.561–0.725, p=0.003) with 72.7% sensitivity and 56.4% specificity. In univariable analysis, age, EF, C-reactive protein, and SUA were significant predictors of CIN, but none remained significant in multivariable analysis. Conclusions: Elevated SUA levels are associated with increased CIN risk in CTO-PCI patients. Routine SUA assessment may identify high-risk patients, supporting enhanced preventive strategies.Keywords : Serum Ürik Asit, Kontrast İnduced Nefropati, Kronik Total Oklüzyon, Perkütan Koroner Girişim, Böbrek hasarlanması.
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