The Use of GLUT-1, Ki-67 and PCNA Antibodies as Immunohistochemical Markers in Histopathological Differential Diagnosis of Psoriasis and Chronic Spongiotic Dermatitits

Authors : Ali MIZRAK

Pages : 169-178

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Publication Date : 2021-08-30

Article Type : Research Paper

Abstract :ABSTRACT Introduction: The present study aims to investigate the benefits of the immunohistochemical antibodies of glucose transporter 1 (GLUT-1), the nuclear protein Ki-67, and proliferating cell nuclear antigen (PCNA) to distinguish between psoriasis and chronic spongiotic dermatitits. Materials and Methods: We evaluated 32 cases of psoriasis and 35 cases of spongiotic dermatitis that had been clinicopathologically diagnosed. Skin tissue from reduction mammoplasty procedures was used as a control group. Skin biopsy sections stained with H&E were examined. Additional immunohistochemistry was performed, including Ki-67, PCNA and GLUT-1. Histological findings were also noted Results: There was no significant difference between psoriasis and chronic spongiotic dermatitits groups in the results of Ki-67 or PCNA staining. GLUT1 distribution was also similar; however, there was a difference between the groups concerning GLUT-1 intensity. The percentage of cases with moderate GLUT-1 staining was higher in the psoriasis group, whereas the percentage of strong staining was higher in the chronic spongiotic dermatitits group. Most of the examined histopathological features of psoriasis and chronic spongiotic dermatitits cases were different. Conclusion: The intensity of GLUT-1 staining with the appropriate histopathological and clinical findings may have a limited benefit in the differential diagnosis of psoriasis and chronic spongiotic dermatitits.
Keywords : chronic spongiotic dermatitits, glucose transporter 1, immunohistochemistry, Ki 67, proliferating cell nuclear antigen, psoriasis