Hyponatremia: More than just an electrolyte for COVID-19 patients

Authors : Serpil Müge DEĞER, Emre YASAR, Hasan Selçuk ÖZGER, Pınar AYSERT YILDIZ, Ulver DERİCİ

Pages : 97-109

Doi:10.18614/deutip.1218114

View : 35 | Download : 39

Publication Date : 2023-09-06

Article Type : Research Paper

Abstract :AIM: Hyponatremia is the most common electrolyte disturbance among infections, especially with pneumonia. Here, we aimed to analyze the presence of hyponatremia among COVID-19 patients along with its relation to mortality. MATERIALS and METHODS: Patients were divided into two groups COVID-19 negative and positive and also another group with pneumonia and without pneumonia for covid-19 PCR positive patients. The association between hyponatremia and in-hospital mortality from any cause was evaluated with univariate and multivariate cox regression model. RESULTS: A total of 636 patients, a mean age of 50± 18 years, 48 % of the female with a median duration of hospitalization of 5.5 insert ignore into journalissuearticles values(IQR, 2,11); days were included. Of those 553 insert ignore into journalissuearticles values(%87); were detected COVID-19 PCR positive and 298 insert ignore into journalissuearticles values(47%); of those with pneumonia. The median serum sodium concentration was lower in COVID-19 PCR positive patients [134 insert ignore into journalissuearticles values(IQR, 130,137); mEq/L] compared to negatives [139 insert ignore into journalissuearticles values(IQR, 136, 140); mEq/L] insert ignore into journalissuearticles values(p<0.001);. The median serum sodium levels were significantly lower in patients with pneumonia [136 insert ignore into journalissuearticles values(IQR, 133.138); mEq/L] than without pneumonia [139 insert ignore into journalissuearticles values(IQR, 137, 145); mEq/L] insert ignore into journalissuearticles values(p<0.001);. All deaths occurred in patients with pneumonia [insert ignore into journalissuearticles values(n=40 insert ignore into journalissuearticles values(13.4 %);]. Patients with hyponatremia had increased mortality on unadjusted insert ignore into journalissuearticles values(OR, 3.85, 95%CI: 1.73, 8.53, P<0.001); and adjusted [OR, 3.58, 95%CI: 1.58, 8.1, P=0.002] in Cox proportional hazard models CONCLUSION: Hyponatremia at admission is prevalent and an independent risk factor for in-hospital mortality among COVID-19 patients particularly those with pneumonia. It might be an important laboratory clue for both the diagnosis and survive of these patients.
Keywords : COVID 19, Hiponatremi, pnömoni, mortalite