Outcomes and Pathological Features of Total Thyroidectomy in Patients with Multifocal Papillary Thyroid Carcinoma

Authors : Seyed Ziaeddin RASİHASHEMİ, Zahra SHİLAN, Samad FARASHİ BONAB, Ebrahim FARASHİ

Pages : 50-55

Doi:10.18678/dtfd.1202143

View : 26 | Download : 17

Publication Date : 2023-04-30

Article Type : Research Paper

Abstract :Aim: The incidence of thyroid cancer has increased dramatically in recent decades. Multifocality is considered a poor prognostic factor for papillary thyroid carcinoma insert ignore into journalissuearticles values(PTC);. Patients with multifocal PTC insert ignore into journalissuearticles values(MPTC); are at high risk for local recurrence, as well as lymphatic and distal metastases. This study examined the features and outcomes of MPTC. Material and Methods: This retrospective study was conducted on 300 patients with PTC. Patients were classified into a multifocal group and a unifocal group. The pathological features of the PTC and the patients’ outcomes were analyzed and compared. Results: The multifocal group included 146 patients insert ignore into journalissuearticles values(48.7%);, while the unifocal group included 154 patients insert ignore into journalissuearticles values(51.3%);. The occurrence of multifocality was higher in females than in males insert ignore into journalissuearticles values(Odds ratio, OR: 2.37, 95% confidence interval, CI: 1.20-4.67, p=0.015);. Tumor size of >1 cm in the multifocal group was larger than in the unifocal group insert ignore into journalissuearticles values(2.5 and 2.2 cm, respectively, p=0.021);. Moreover, in multifocal group higher moderate risk of recurrence was detected than in the unifocal group insert ignore into journalissuearticles values(OR: 1.63, 95% CI: 1.01-2.60, p=0.044);. At follow-up after treatment, MPTC patients had higher lymph node metastasis insert ignore into journalissuearticles values(OR: 2.89, 95% CI: 1.23-6.80, p=0.014);. In addition, significantly higher thyroglobulin plasma levels insert ignore into journalissuearticles values(p=0.026); and disease recurrence insert ignore into journalissuearticles values(OR: 2.41, 95% CI: 1.05-5.52, p=0.037); were found in the multifocal group compared to the unifocal group. Conclusion: Patients with MPTC had a higher risk of disease recurrence, and multifocality was concluded to be an independent prognostic factor for overall disease recurrence.
Keywords : papiller tiroid karsinomu, tiroidektomi, multifokalite, nüks