The Relationship Between Immune Inflammation Index and Major Cardiovascular Adverse Events in Patients with Heart Failure with Reduced Ejection Fraction.

Authors : Osman Bektaş, Fatih Akkaya

Pages : 6-12

Doi:10.33713/egetbd.1412399

View : 36 | Download : 41

Publication Date : 2024-05-14

Article Type : Research Paper

Abstract :Aim: We aimed to investigate whether systemic immune inflammation index (SII) has a predictive value in predicting prognosis and major adverse cardiovascular events such as exitus, stroke and hospitalization in heart failure patients with reduced ejection fraction (HFrEF). Methods: Patients over the age of 18 who applied to the cardiology and emergency outpatient clinics between January 2019 and January 2022 and diagnosed with HFrEF (Ejection Fraction <40%) were retrospectively screened. A total of 597 patients with reliable clinical data were included in the study.The relationship between major adverse cardiovascular events and SII was evaluated. Exitus, stroke and hospitalization were accepted as major adverse cardiovascular events. Result: In patients with HFrEF, SII index was found to be significantly higher in the Exitus (+) group (1504.34±1722.74) when compared with the Exitus (-) group (893.94±972.13) (p=0.014). On the other hand, SII index was not found to be different between the patients with or without stroke and between those with or without hospitalization. When the correlation between the SII index and presence of exitus, stroke, and hospitalization was evaluated, a significant positive correlation was found between the presence of exitus and SII index (r=0.165 p<0.001). A SII index value of 697.29 was found to predict exitus with 604% sensitivity and 607% specificity in heart failure patients (AUC: 0.621,95%CI 0.539-0.704, p=0.04) Conclusion: SII index, which can be calculated easily from lymphocyte, platelet and neutrophil counts, predicts mortality in patients with HFrEF. This index has prognostic significance in patients with HFrEF, suggesting that closer monitoring of elderly patients with a high SII index may be beneficial.
Keywords : immun enflamasyon indeksi, kalp yetersizliği, ejeksiyon fraksiyonu