Effects of Potassium Dichromate and Boron on Oxidative Stress and DNA Damage in Rats

Authors : Meryem Eren, Meryem Şentürk

Pages : 162-167

Doi:10.32707/ercivet.1587330

View : 48 | Download : 42

Publication Date : 2024-12-02

Article Type : Research Paper

Abstract :In this study, the effects of potassium dichromate (K2Cr2O7) and boron (B, as boric acid) on oxidative stress and DNA damage in rat serum and liver were investigated. Sixty female Sprague-Dawley rats were divided into six groups of 10 animals each. The first group was kept as the control group. The second and third groups received 5 and 10 mg/kg B, respectively, the forth group received 10 mg/kg K2Cr2O7, and the fifth and sixth groups received 5 and 10 mg/kg B plus K2Cr2O7, respectively, orally for two weeks. Compared with the control groups, serum MDA levels increased (P<0.01) and TAC levels decreased (P<0.001) in the K2Cr2O7 group. Serum MDA levels decreased in the K2Cr2O7+5 and 10 mg/kg B groups, but a significant decrease was found in the K2Cr2O7+10 mg/kg B group (P<0.01). Serum TAC levels showed a numerical increase in K2Cr2O7+B groups. The liver MDA level was significantly decreased in the K2Cr2O7+10 mg/kg B group compared to the other groups (P<0.01). There was no difference in plasma 8-OHdG levels between the groups. A positive correlation was observed between liver B and Cr levels (P<0.05). In this study, serum MDA and TAC levels were negatively affected in rats administered 10 mg/kg K2Cr2O7. In contrast, administration of 10 mg/kg B to the K2Cr2O7 group had positively effected on serum and liver lipid peroxidation indicators.
Keywords : Bor, DNA hasarı, oksidatif stres, potasyum dikromat, rat