Synthesis and Characterization of Poly(lactic-co-glycolic acid) Derived with LGlutamic Acid and L-Aspartic Acid

Authors : Gülce TAŞKOR ÖNEL

Pages : 155-168

Doi:10.18185/erzifbed.1235522

View : 12 | Download : 16

Publication Date : 2023-03-31

Article Type : Research Paper

Abstract :Polyinsert ignore into journalissuearticles values(lactic-co-glycolic acid); insert ignore into journalissuearticles values(PLGA); is a biocompatible, biodegradable polymer approved by the FDA and EMA, which is the most widely used in the field of health. In this study, PLGA was synthesized primarily from lactide and glycolide by polycondensation and ring-opening polymerization. Then, amino acid derivatives of PLGA were synthesized by the reaction of PLGA and amino acids in the presence of 1-ethyl-3-insert ignore into journalissuearticles values(3-dimethylaminopropyl);carbodiimide insert ignore into journalissuearticles values(EDC);. The polymers synthesized were PLGA, PLGA-L-glutamic acid insert ignore into journalissuearticles values(PLGA-G);, and PLGA-L-aspartic acid insert ignore into journalissuearticles values(PLGA-A);. The chemical structure of these polymers was confirmed by 1H and 13C Nuclear Magnetic Resonance insert ignore into journalissuearticles values(1H NMR and 13C NMR);, Fourier Transform Infrared Spectroscopy insert ignore into journalissuearticles values(FTIR);, Differential Scanning Calorimetry insert ignore into journalissuearticles values(DSC);, and Gel Permeation Chromatography insert ignore into journalissuearticles values(GPC);. When the 13C NMR analyses of PLGA-amino acid derivatives were observed, an increase in the number of carbonyl carbons around 170 ppm was found and the structure accuracy was supported. In addition, when the FTIR analyses of PLGA-amino acid derivatives were examined, the structure was confirmed by observing the signal of the amide bond carbonyl vibration at 1700 cm-1. While the typical endothermic thermogram of the PLGA-amino acid derivative structures was observed by DSC analysis, it was shown that the structures were low molecular weight polymers [~5000-6000 Da] by GPC analysis.
Keywords : PLGA, amino asit, biyobozunur polimer