THE CLINICAL SIGNIFICANCE OF SOX9 GENE IN DIFFERENT CANCER TYPES:AN IN-SILICO ANALYSIS

Authors : Ethem Serhat Yavaş, Sedef Hande Aktaş, Göksel Efendioğlu, Dilara Fatma Akın

Pages : 63-73

Doi:10.18036/estubtdc.1312624

View : 48 | Download : 58

Publication Date : 2024-07-30

Article Type : Research Paper

Abstract :One of the common problems in the pathogenesis of human cancer is characterized as the dysregulation of transcription factors. SOX9 is important as it is one of the critical transcription factors involved in various diseases, including cancer. In addition, SOX9 also acts as a proto-oncogene or tumor suppressor gene, depending on the cancer type. In this study, we aimed to reveal the mutation and expression status of the SOX9 transcription factor and the effect of this gene on the survival of patients with different cancer groups. The data sets for expression analysis and overall survival analysis were performed by the GEPIA database. Analysis of the mutation profile was performed by the cBio database. As a result, SOX9 gene expressions were significantly elevated in BLCA, CESC, CHOL, COAD, ESCA, GBM, KIRP, LGG, LIHC, LUSC, OV, PAAD, READ, SKCM, STAD, TGCT, THYM, UCEC and UCS in cancer tissues compared to that in normal tissues (p<0.05). According to overall survival (OS) analysis; the SOX9 gene has a significant relationship with OS in ACC, CESC, KIRC, LGG, and THYM (ACC p:0.0079, CESC p:0.038, KIRC p:0.051, LGG p:0.00055, THYM p:0.031). A total of 170 mutations in SOX9 were determined according to mutation analysis. Seventy-six of them were detected as driver mutations. The analysis shows that SOX9 expression status has a different effect in each cancer type, and although there is no significant mutation in the SOX9 gene in ACC cancer type, high expression of this gene is important for survival. Therefore, it is of great importance to analyze the epigenetic changes in the SOX9 gene in ACC cancer type. The analysis also indicates that the SOX9 gene is discriminatory for the survival of adrenocortical carcinoma, cervical squamous cell carcinoma and endocervical adenocarcinoma, renal clear cell carcinoma, brain low-grade glioma and thymoma cancer types.
Keywords : SOX9, Transkripsiyon faktörü, gen ifadesi, mutasyon, sağkalım