Central Composite Design for the Development of Trimetazidine Dihydrochloride-Loaded Fast Dissolving Film

Authors : Swapnil CHOPADE, Santosh A PAYGHAN

Pages : 61-74

Doi:10.55262/fabadeczacilik.1085351

View : 28 | Download : 17

Publication Date : 2023-03-01

Article Type : Research Paper

Abstract :A fast-dissolving dosage form is an approach used to improve therapeutic efficacy and bioavailability by avoiding the first-pass metabolism of the cargo. Besides, the approach causes rapid cargo absorption from the pre-gastric area which may outcome in the quick inception of action. The trimetazidine dihydrochloride insert ignore into journalissuearticles values(TDC); is an anti-anginal drug and there is a prerequisite to provide fast onset of action to treat angina. Therefore, the present work was aimed to prepare and evaluate fast-dissolving oral films insert ignore into journalissuearticles values(FDOF); of TDC to provide fast onset of action. The FDOF is prepared by using the solvent casting method and it was optimized by employing a central composite statistical design. The two independent variables such as HPMC K4M and PEG 400 are the film-forming polymers which are evaluated at three levels. The dependent variables selected as folding endurance, disintegration time, and % drug release. The formulation was prepared and optimized the batch F-4 showed the least disintegration time insert ignore into journalissuearticles values(19 s); and the highest drug release insert ignore into journalissuearticles values(98.55±7.90%);. Moreover, the ex-vivo mucus permeation study showed better permeation and satisfying physicochemical properties. As per the above results, we conclude that the prepared formulation could be a novel dosage form to improve drug delivery and patient compliance.
Keywords : Anti anginal, CCD, Ex vivo permeation, fast dissolving oral film, Solvent casting method, Trimetazidine dihydrochloride