Monoclonal Antibodies and Immuno-PET Imaging: An Overview

Authors : Elif Tugce SARCAN, Yekta ÖZER

Pages : 165-182

Doi:10.55262/fabadeczacilik.1172020

View : 29 | Download : 14

Publication Date : 2023-03-01

Article Type : Review Paper

Abstract :Radiopharmaceuticals are radioactive medicines used for imaging and/or therapeutic purposes, consisting of radionuclidic and pharmaceutical parts. While PET and SPECT methods are used for imaging purposes, immuno-PET imaging method has gained popularity, recently. Immuno-PET imaging method, is a combination of PET radionuclides and biomolecules, especially monoclonal antibodies insert ignore into journalissuearticles values(mAb);, proteins, peptides, are frequently used for the imaging of different types of cancer. Radionuclides with long half-lives are generally used in immuno-PET imaging. Long biological half-lives of mAbs is the most important reason to be preferred for immuno-PET imaging. Today, Zirconium-89 insert ignore into journalissuearticles values(Zr-89);, Iodine-124 insert ignore into journalissuearticles values(I-124); with long half-lives and Copper-64 insert ignore into journalissuearticles values(Cu-64); and Yttrium-86 insert ignore into journalissuearticles values(Y-86); radionuclides with relatively long half-lives are preferred in immuno-PET imaging. In this article, studies on Zr-89, Cu-64, I-124 and Y-86-labeled mAbs with long half-life and clinical and preclinical studies were reviewed. Also, comparison of these 4 radionuclides, which are frequently used in the labelling of biomolecules insert ignore into journalissuearticles values(particularly mAbs); with is included.
Keywords : immuno PET, Zirconium 89, Copper 64, Yttrium 86, Iodine 124, Monoclonal Antibodies, Imaging