Antifungal Activity of Ethanol Extract Desmanthus virgatus (L.) Leaves In Silico and In Vitro

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Fabad Eczacılık Bilimler Dergisi
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Antifungal Activity of Ethanol Extract Desmanthus virgatus (L.) Leaves In Silico and In Vitro

Antifungal Activity of Ethanol Extract Desmanthus virgatus (L.) Leaves In Silico and In Vitro

Authors : Tukiran Tukiran, Lilik Farkhiyah, Marshellia Ghinanda Dewistamara

Pages : 329-342

Doi:10.55262/fabadeczacilik.1586787

View : 69 | Download : 36

Publication Date : 2025-08-26

Article Type : Research Paper

Abstract :Most fungal human infections are caused by Candida species, especially Candida albicans. C. albicans is a highly adaptable microorganism that can cause resistance after prolonged exposure to antifungals. C. albicans fungus is easily transmitted so that the discovery of new antifungal agents is very urgent. Therefore, this study aims to find antifungal agents from natural materials, namely wild tantan leaves in silico and in vitro. In the in silico test, 10 dominant compounds from LC-MS results using 2QZX protein obtained 3 compounds that have the most potential as antifungals with binding affinity values lower than ketoconazole. On the other hand, in the in vitro test with the agar diffusion method using disc paper, the average inhibition zone value was 0,01283 m and was classified as strong.
Keywords : Antifungal, wild tantan, Candida albicans, in silico, in vitro

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