Ibuprofen Loaded Sodium Alginate Sponges for Acute Wound Treatment

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Fabad Eczacılık Bilimler Dergisi
Cilt: 50 Sayı: 3
Ibuprofen Loaded Sodium Alginate Sponges for Acute Wound Treatment

Ibuprofen Loaded Sodium Alginate Sponges for Acute Wound Treatment

Authors : Kadir Aykaç, Ceyda Köroğlu Özmen

Pages : 689-706

Doi:10.55262/fabadeczacilik.1783441

View : 81 | Download : 135

Publication Date : 2025-10-30

Article Type : Research Paper

Abstract :In this study, ibuprofen-loaded sodium alginate sponge formulations were developed for use in wound healing. Sodium alginate solutions at two different concentrations were dried using a lyophilizer to obtain drug delivery systems in the form of sponges containing various concentrations of ibuprofen. The prepared formulations were characterized for critical properties including water-holding capacity, molecular interactions (FTIR), tissue elasticity (texture analysis), drug content, drug release kinetics, and cytotoxicity. The results showed that the sponges could absorb water up to 5 times their own weight and dissolved completely within 2 hours, with a faster drug release observed compared to pure ibuprofen. Drug release kinetics revealed that Formulation A followed a first-order kinetic model, while Formulation B conformed to the Hopfenberg model. Cytotoxicity tests indicated that pure ibuprofen exhibits dose-dependent toxicity, but this was significantly reduced when incorporated into the sodium alginate formulation. Overall, the findings suggest that ibuprofen-loaded sodium alginate sponges have a high potential for use in wound treatment.
Keywords : yara tedavisi, ibuprofen, sünger

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