Embryological Origins and Genetics in Frontotemporal Dementia

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Ahi Evran Tıp Dergisi
Cilt: 9 Sayı: 3
Embryological Origins and Genetics in Frontotemporal Dementia

Embryological Origins and Genetics in Frontotemporal Dementia

Authors : Zeynep Hayırlıoğlu, Zeliha Yücel, Emine Berrin Yüksel

Pages : 397-402

Doi:10.46332/aemj.1652578

View : 15 | Download : 73

Publication Date : 2025-12-22

Article Type : Review Paper

Abstract :Frontotemporal dementia (FTD) represents a heterogeneous group of neurodegenerative disorders marked by progressive deterioration in behavior, language, and executive function. While its genetic architecture dominated by mutations in C9orf72, GRN, and MAPT has been widely studied, less attention has been given to how early neurodevelopmental processes may shape regional vulnerability. This review integrates current findings in molecular genetics with insights from embryonic development of the frontal and temporal lobes. Key signaling pathways such as Wnt, SHH, and Notch are examined in the context of FTD-related pathology. Emphasis is placed on how embryological disruption may predispose cortical regions to later neurodegeneration. The clinical implications of these developmental-genetic interactions are also explored, underscoring their relevance in future biomarker discovery and therapeutic targeting.
Keywords : embriyoloji, frontotemporal demans, genetik, moleküler yolaklar, nörodejenerasyon

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