Characterization of Thermosensitive Gels for the Sustained Delivery of Dexketoprofen Trometamol for Dermal Applications

Authors : Özlem ÇULCU, Emre TUNÇEL, Sibel İLBASMIŞ TAMER, Fahriye Figen TIRNAKSIZ

Pages : 1-12

View : 26 | Download : 14

Publication Date : 2020-10-19

Article Type : Research Paper

Abstract :In this report, the release properties of dexketoprofen (DEX) from propylene glycol (PG) and poloxamer gel systems were investigated. After formulation of gel systems composed of poloxamer 338 and PG, rheological experiment was conducted to investigate effects of PG on temperature-dependent viscoelasticity of poloxamer 338-based gels. It appeared that PG and poloxamer 338 could form gel systems with good thermosensitive properties, the gel system containing 2.5% and 5% PG showed similar thermosensitive properties. In vitro release studies were performed at two different temperatures, room temperature (25 ̊C ± 0.1 ̊C) and skin temperature (32 ̊C ± 0.1 ̊C), using Franz diffusion cells and showed decreased the release rate of DEX at skin temperature (32 ̊C) according the thermosensitive properties of poloxamer 338. Also released amount of DEX were decreased due to the use of high poloxamer concentration. At both temperatures, the highest release (39.35% at 32 °C and 31.78% at 25 ̊C in 8 hours) was obtained with 20%poloxamer + 5%PG, the lowest release (29.46% at 32 °C and 26.23% at 25 ̊C in 8 hours) was obtained with 25% poloxamer + 5% PG. After the drug releaseamount was examined, kinetic models (zero order, first order, Higuchi, Hixson-Crowell and Korsmeyer-Peppas) were investigated. In both temperatures (25 ̊C and 32 ̊C), the in vitro drug release profiles of poloxamer based formulations were fit to the Korsmeyer-Peppaskinetic model.
Keywords : Poloxamer, sustained release, viscosity, dexketoprofen trometamol, propylene glycol