The Effect of Dexmedetomidine on Oxidative Balance in Lung, Liver and Heart: Rat Sepsis Model

Authors : Rahim KOCABAŞ, Sinan Oğuzhan ULUKAYA, Eyüp Fatih CİHAN, Alper YOSUNKAYA

Pages : 95-99

Doi:10.54005/geneltip.1224337

View : 41 | Download : 14

Publication Date : 2023-02-28

Article Type : Research Paper

Abstract :Aim: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Early intervention in sepsis is vital and research on the subject continues. Having sedative, analgesic, and anxiolytic properties, Dexmedetomidine insert ignore into journalissuearticles values(DEX); is a potent lipophilic α2‐adrenoceptor agonist with imidazole structure. In recent years, there has been an increasing number of studies on the organ protective effects of DEX. Unlike other studies, in this project proposal, it was aimed to investigate the effect of DEX applied in different periods of sepsis on the oxidative stress index in the lungs, liver and heart. Material and methods: The study was approved by the Necmettin Erbakan University Experimental Animals Ethics Committee insert ignore into journalissuearticles values(2020 – 017);. In the study, 50 female wistar albino rats were used as experimental animals. Animals were divided into five groups: 1st group: SHAM insert ignore into journalissuearticles values(n:10);, 2nd group: SEPSIS insert ignore into journalissuearticles values(n:10);, 3rd group: DEX insert ignore into journalissuearticles values(PreDEX, n:10); applied 30 minutes before cecal ligation puncture insert ignore into journalissuearticles values(CLP); procedure, group 4: DEX administered 12 hours after CLP insert ignore into journalissuearticles values(Post12DEX, n:10);, group 5: DEX administered 24 hours after CLP insert ignore into journalissuearticles values(Post24DEX, n:10);. Results: In liver and heart tissues, the decrease in total antioxidant status insert ignore into journalissuearticles values(TAS); levels in the SEPSIS group was statistically significant compared to the Post12DEX insert ignore into journalissuearticles values(p <0.001 and p <0.001); and Post24DEX insert ignore into journalissuearticles values(p =0.007 and p <0.05); groups. In lung, liver and heart tissues, the increase in the oxidative stress index insert ignore into journalissuearticles values(OSI); levels in the SEPSIS group, compared to the PreDEX insert ignore into journalissuearticles values(p =0.007, p =0.003, p <0.001); group, was statistically significant. Conclusion: DEX applied until the 24th hour after CLP for liver tissue contributes positively to reducing the OSI index of DEX applied until the 12th hour for heart tissue, but it contributes to reducing the DEX OSI index applied only before CLP for lung tissue.
Keywords : Dexmedetomidine, Sepsis, Oxidative stress index, Lung, Liver, Heart

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