Long-term Survival Outcomes of Early-stage Grade 1 and 2 EndometrioidType Endometrial Cancer Patients

Authors : Fazıl AVCI, Orhan Önder EREN, Ahmet BİLGİ, Hamit BAŞARAN, Murat CELİK, Melek CAGLAYAN, Cetin CELİK

Pages : 232-238

Doi:10.54005/geneltip.1265954

View : 15 | Download : 9

Publication Date : 2023-04-30

Article Type : Research Paper

Abstract :Aims: Early-stage endometrioid-type endometrial cancer insert ignore into journalissuearticles values(EC); has a favorable prognosis. The recurrence is still the biggest issue. There are differences in the literature in terms of treatment modalities in early-stage. We investigated long-term survival outcomes of early-stage grade 1 and 2 endometrioid-type EC patients. Methods: Out of 327 cases, 294 cases in stage 1 and 33 cases in stage 2 were evaluated. Age, stage, tumor size, histologic grade, degree of myometrial invasion, presence of lymphovascular invasion insert ignore into journalissuearticles values(LVSI);, peritoneal cytology positive, presence of recurrence, overall survival insert ignore into journalissuearticles values(OS);, and disease-free survival insert ignore into journalissuearticles values(DFS); between two groups were evaluated statistically. Results: The mean age of 327 patients was 64.0±10.0 years. Out of 327, 65.7% were ≥60 years, 90% were stage 1, 74.6% were grade 1, 1.8% had positive peritoneal cytology, 8.3% had LVSI and 86% had ≤50% myometrial invasion. Recurrence was detected in 6.4% of patients. 40.7% of patients received adjuvant radiotherapy. Only the adjuvant radiotherapy was found a significant association between two groups. Only presence of recurrence in terms of OS and DFS durations was a significant parameter in the regression analysis. Conclusions: Development of recurrence in early-stage endometrioid-type EC is the main prognostic predictor for survival. The early diagnosis and treatment of recurrence have a positive impact on the prognosis.
Keywords : endometrioid, endometriyal kanser, rekürrens, survi