Evaluation of C-Reactive Protein to Albumin Ratio and Systemic Inflammation in Postmenopausal Osteoporosis

Authors : Esra Şahingöz Bakırcı, Mustafa Bakırcı

Pages : 334-339

Doi:10.54005/geneltip.1439038

View : 27 | Download : 25

Publication Date : 2025-04-30

Article Type : Research Paper

Abstract :Aim We aimed to evaluate systemic inflammation in patients with postmenopausal osteoporosis using C-reactive protein (CRP)/albumin ratio, blood neutrophil/lymphocyte ratio (NLR) and prognostic nutritional index (PNI) and to determine its relationship with bone mineral density (BMD). Methods Our study has a retrospective design. A total of 363 postmenopausal female patients admitted to physical medicine and rehabilitation outpatient clinics were evaluated. Patients were divided into three groups as osteoporosis, osteopenia and normal BMD. Demographic data, femoral neck and lumbar total T scores, BMD values, complete blood count parameters, CRP and albumin results were recorded. CRP/albumin ratio, NLR and PNI were calculated. Results Osteoporosis was found in 102, osteopenia in 167 and normal BMD in 94 patients. In the osteoporosis group, albumin, CRP and CRP/albumin ratio were lower than the normal BMD group (p = 0.017; p < 0.001; p = 0.032, respectively). In the osteoporosis group, PNI was lower than the other groups (p < 0.001). NLR was higher in the osteoporosis group than the other groups, but not statistically significant (p = 0.723). We found a positive correlation between BMD with albumin and PNI. Conclusion The effect of inflammatory response in postmenopausal osteoporosis is not prominent. CRP/albumin ratio does not seem to be an appropriate index for osteoporosis. In the light of our data, nutritional factors seem to be more effective on osteoporosis.
Keywords : Albümin, CAR, inflamasyon, osteoporoz, PNİ