Clinical Characteristics and EEG Findings of Patients with Childhood Absence Epilepsy

Authors : Mehmet Baştemur, Haci Nadir Yalçın, Neslihan Bilgin, Mutluay Arslan, Bülent Ünay

Pages : 1178-1189

Doi:10.54005/geneltip.1708309

View : 89 | Download : 172

Publication Date : 2025-12-31

Article Type : Research Paper

Abstract :Abstract Aim This study aimed to describe the clinical features and electroencephalographic (EEG) findings of patients with childhood absence epilepsy (CAE) and to evaluate the relationship of these parameters with treatment response. Methods Twenty-one patients diagnosed with childhood absence epilepsy (CAE) between 2021 and 2024 were included in the study. Demographic data, seizure characteristics, timing of treatment initiation, clinical examination findings, baseline EEG recordings, and treatment responses during follow-up were retrospectively analyzed. Pre-treatment EEG recordings were re-evaluated by a pediatric neurologist. Results Twenty-one patients were included. The mean age at seizure onset was 7.3 years (range: 4.5 to 11 years). The gender distribution was almost equal: 47.6% girls and 52.4% boys. Approximately one-third of the patients had accompanying motor components. During the hyperventilation test, seizures were observed in 15 cases (71.4%) and spike-wave discharges in EEG were seen in 18 (85.7%). Epileptic discharges were detected in four cases (19%) during intermittent photic stimulation. The duration of discharges in EEG was most frequently in the range of 1-10 seconds. Focal fragments were detected in six patients (28%), and OIRDA in five ( 23%). Complete treatment response was achieved in 90.9% of patients with ≤4 discharges frequency and in 70% of those with >4 discharge frequency. All patients initially treated with ethosuximide achieved complete seizure control, whereas response rates were lower in the valproate and lamotrigine groups. Patients who started treatment within three months had higher response rates. No seizures were observed in subsequent follow-ups of patients who achieved early complete response. Conclusion Combined evaluation of clinical and EEG findings in CAE is crucial for treatment planning and prognosis estimation. Although focal findings do not always indicate a poor outcome, they should be interpreted with caution.
Keywords : İdiyopatik jeneralize epilepsi, Çocukluk çağı absans epilepsisi, Absans nöbetleri, Elektroklinik özellikler, Terapötik sonuçlar

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